Abstract
In order to investigate the distribution and significance of receptors for Helix pomatia agglutinin (HPA), paraffin sections from several reactive and 70 neoplastic lymphoid tissues were utilized for a histochemical study after neuraminidase treatment. Lymphocytes in the germinal center and thymic cortex were mostly negative for the receptors, while most of the lymphocytes in the thymus-dependent area, some of those in the primary follicle or in the marginal zone and most of the plasma cells in the medulla possessed the receptors on their surfaces. Nodular lymphomas, thymomas, and diffuse lymphoblastic lymphomas were mostly negative in contrast to the positive reaction in diffuse poorly differentiated lymphomas of B-cell type and plasmocytomas. Diffuse histiocytic lymphomas and diffuse mixed lymphocytic and histiocytic lymphomas occasionally possessed the receptors, irrespective of their immunological markers. Hodgkin's cells were negative on their surface, but were occasionally positive in their cytoplasms ans seen in case of histiocytes. From these results, HPA receptors could be neither T-cell nor B-cell differentiation marker. The possibility that HPA-receptor-negative lymphocytes may hav a quick turn-over rate or a short l...Continue Reading
References
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·T O LandaasT B Halvorsen
Sep 1, 1979·Acta Pathologica Japonica·A MikataK Kageyama
Jun 30, 1977·Nature·I MiyoshiH Masuji
Dec 1, 1977·Cancer·I MiyoshiI Kimura
Nov 15, 1977·International Journal of Cancer. Journal International Du Cancer·L C AnderssonH Wigzell
Nov 1, 1978·European Journal of Immunology·B AxelssonH Mellstedt
Jan 1, 1977·Scandinavian Journal of Immunology·R H SwanborgP Perlmann
Mar 1, 1978·Scandinavian Journal of Immunology·U HellströmS Hammarström
Jun 14, 1977·Biochemistry·S HammarströmM E Etzler
Jan 1, 1976·Scandinavian Journal of Immunology·U HellströmP Perlmann
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·H S Kaplan, S Gartner
Jun 1, 1976·Scandinavian Journal of Immunology·U HellströmP Perlmann
Dec 1, 1975·Experimental Cell Research·M L DillnerP Perlmann
Jul 1, 1969·Biochemistry·S Hammarström, E A Kabat
Feb 1, 1966·The Journal of Experimental Zoology·R Rappaport
Nov 1, 1973·The Journal of Experimental Medicine·S HammarströmM L Dillner
Oct 10, 1972·Biochemistry·S ToyoshimaT Osawa
Jan 1, 1973·Scandinavian Journal of Immunology·S Hammarström
Jan 1, 1970·Annual Review of Biochemistry·R G Spiro
Jan 1, 1980·Blut·H U SchwenkK H Herzog
Aug 30, 1973·Biochimica Et Biophysica Acta·I J GoldsteinP A Gorin