PMID: 8597413Dec 29, 1995Paper

Receptors for melanocortin peptides in the hypothalamic-pituitary-adrenal axis and skin

Annals of the New York Academy of Sciences
C TsigosG P Chrousos

Abstract

The syndromes of hereditary IGD and triple A syndrome are potentially life threatening and severely disabling diseases. Clinical awareness of these syndromes is of considerable prognostic and therapeutic importance. The defects in the ACTH receptor causing IGD help illuminate the mechanisms of ligand binding and signal transduction by this receptor. Identification of the molecular defect(s) responsible for IGD cases with a normal ACTH receptor structural gene and for the triple A syndrome remains a challenge, which will hopefully eventually provide further insight into the mechanisms of adrenocortical function. The cloning of the melanocortin receptors has been a giant step towards a better insight into the physiological role of the POMC-derived peptides. It is now becoming apparent that the differential processing of POMC in the brain, the pituitary, and peripheral tissues, yielding a number of different biologically active melanocortin peptides, combined with the distinct tissue distribution and pharmacological profile of the melanocortin receptors will help elucidate the molecular basis of these functions.

References

Apr 1, 1975·Archives of Disease in Childhood·D ThistlethwaiteR A Harkness
Mar 4, 1992·JAMA : the Journal of the American Medical Association·G P Chrousos, P W Gold
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·L F AllenS Cotecchia
Aug 10, 1990·Science·J LyonsH R Bourne
Nov 8, 1990·The New England Journal of Medicine·T P DryjaE L Berson
Dec 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·D I Buckley, J Ramachandran
Aug 1, 1994·Mammalian Genome : Official Journal of the International Mammalian Genome Society·R E MagenisR D Cone
Jan 1, 1994·The Journal of Endocrinology·G HuntA J Thody
May 16, 1994·Biochemical and Biophysical Research Communications·I GantzT Yamada
Feb 1, 1994·Molecular and Cellular Endocrinology·K G MountjoyR D Cone
May 31, 1993·Annals of the New York Academy of Sciences·D de Wied
May 31, 1993·Annals of the New York Academy of Sciences·R D ConeM T Mortrud
May 31, 1993·Annals of the New York Academy of Sciences·W LichtensteigerA N Eberle
Sep 15, 1993·Biochemical and Biophysical Research Communications·V ChhajlaniJ E Wikberg
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L Roselli-RehfussR D Cone
Apr 1, 1993·The Journal of Steroid Biochemistry and Molecular Biology·G Aguilera

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Citations

Oct 22, 2003·Molecular Genetics and Metabolism·Robert Clipsham, Edward R B McCabe
Mar 14, 2000·Archives of Medical Research·C Tsigos
Nov 10, 2000·Biochemical and Biophysical Research Communications·A GrützkauM Artuc

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