PMID: 18407113Oct 1, 1992Paper

Receptors for pituitary adenylate cyclase-activating polypeptide: comparison with vasoactive intestinal peptide receptors

Trends in Endocrinology and Metabolism : TEM
A Arimura

Abstract

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a new member of the secretin glucagon-vasoactive intestinal peptide (VIP) family of peptides, being most homologous to VIP. PACAP exists in two amidated forms with 38 residues (PACAP38) and 27 residues (PACAP27), respectively. PACAP38 is the major form in tissues. There are two types of high-affinity receptors for PACAP: type I, which specifically binds to both PACAPs, and type II, which is shared with VIP. Type I PACAP receptors appear to have two subtypes: type IA, which binds to both PACAP38 and PACAP27, with slight preference for the latter, and type IB, with greater preference for PACAP38. Distribution of the type I PACAP receptor is different from that of VIP, and it is found in high concentrations in brain, spinal cord, anterior pituitary, adrenal medulla, spermatogonia at certain stages, mature spermatozoa, and some cell lines. Type II PACAP receptors are found in lung, liver, intestine, and other tissues, and their distribution is similar to that of the VIP receptor. Type II PACAP receptor might be similar to or identical with the VIP receptor.

References

Jan 15, 1992·Biochemical and Biophysical Research Communications·T WatanabeM Fujino
Mar 1, 1992·Trends in Pharmacological Sciences·S NagataG Vassart
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S P SreedharanE J Goetzl
Feb 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·P E GottschallA Arimura
Sep 14, 1990·Biochemical and Biophysical Research Communications·T OhtakiM Fujino
Oct 30, 1990·Biochemical and Biophysical Research Communications·Y MasudaM Fujino
Nov 30, 1990·Biochemical and Biophysical Research Communications·T WatanabeM Fujino
May 16, 1990·Biochemical and Biophysical Research Communications·I TatsunoA Arimura
Oct 16, 1989·Biochemical and Biophysical Research Communications·A MiyataD H Coy
Jan 1, 1988·Annals of the New York Academy of Sciences·M Laburthe, A Couvineau
Jul 1, 1985·The Journal of Clinical Endocrinology and Metabolism·A Couvineau, M Laburthe

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Citations

Feb 21, 1994·European Journal of Pharmacology·S F Nilsson
Dec 15, 1994·Journal of the Autonomic Nervous System·J R GriderJ G Jin
Apr 1, 1994·Trends in Pharmacological Sciences·T Harmar, E Lutz
Mar 31, 1994·Biochimica Et Biophysica Acta·N Rodríguez-HencheJ C Prieto
Jan 1, 1995·Peptides·C YokotaK Yamashita
Apr 4, 1998·Brain Research. Molecular Brain Research·V D'Agata, S Cavallaro
Oct 16, 1999·Brain Research. Molecular Brain Research·K PeetersF Vandesande
Nov 11, 1999·British Journal of Pharmacology·E M LutzR Mitchell
Oct 31, 1994·Annals of the New York Academy of Sciences·A ArimuraD E Brenneman
Feb 17, 2000·Annals of the New York Academy of Sciences·P Gressens
May 15, 2013·Zhurnal evoliutsionnoĭ biokhimii i fiziologii·A O ShpakovN O Motovilova
Jul 31, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·Marzia BarberiRita Canipari
May 18, 2010·Respiratory Physiology & Neurobiology·Melissa M J Farnham, Paul M Pilowsky
Sep 29, 1999·Pulmonary Pharmacology & Therapeutics·L Lindén
May 21, 2013·Molecular and Cellular Endocrinology·Marzia BarberiRita Canipari
Mar 4, 2018·The Journal of Headache and Pain·Dora ReglodiAntoinette MaassenVanDenBrink
Oct 3, 2012·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Marisa AgneseMarina Prisco
Mar 1, 1997·Zentralblatt für Veterinärmedizin. Reihe A·P GuilloteauJ W Blum
Dec 24, 1997·Nature·W Henn, K D Zang

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