PMID: 2461235Oct 1, 1988

Receptors for polysaccharides of group A streptococci on human thymic lymphocytes. Stimulation of their expression by action of adenosine, theophylline and supernatant of thymocytes

Biulleten' eksperimental'noĭ biologii i meditsiny
E V GnezditskaiaL A Malkina

Abstract

It was established by indirect immunofluorescence that thymic lymphocytes bear receptors for polysaccharide of group A streptococci (Rps). The ability of thymic lymphocytes to express Rps depends on the cAMP concentration in the cell, because the treatment of thymocytes with adenosine and theophylline increases the number of cells with Rps (Tps cells). Supernatant of thymic lymphocytes is also capable of stimulating expression of Rps. Because the A-polysaccharide has common antigenic determinant with thymus epithelium antigen it can be assumed that A-polysaccharide links with the thymocytes via receptor for this epithelial antigen. This assumption needs a detailed study in view of the hypothesis about the important role of cross-reactive antigens of group A streptococci in generating autoimmune process during rheumatic fever and other streptococcal diseases. It should also be noted that Rps may be a useful marker for identification and studying the changes of Tps subpopulation in the thymus and peripheral lymphoid organs of patient with different streptococcal diseases.

Citations

Feb 1, 1976·Biulleten' eksperimental'noĭ biologii i meditsiny·L V BeletskaiaI I Rassokhina
Sep 10, 1981·Nature·F Lepault, I L Weissman
Nov 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·E V GnezditskaiaK L Shakhanina

Related Concepts

Immunofluorescence Assay
T-Lymphocyte
Adenosine
Lymphocytes as Percentage of Blood Leukocytes (Lab Test)
Neoplasm of Uncertain or Unknown Behavior of Thymus
Antigenic Specificity
Thymocyte
Streptococcus
Indirect Immunofluorescence
Epithelium

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