PMID: 10564229Nov 24, 1999Paper

Receptors for PTH and PTHrP: their biological importance and functional properties

The American Journal of Physiology
M MannstadtT J Gardella

Abstract

The type 1 receptor (PTH1R) for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP) is a G protein-coupled receptor that is highly expressed in bone and kidney and mediates in these tissues the PTH-dependent regulation of mineral ion homeostasis. The PTH1R also mediates the paracrine actions of PTHrP, which play a particularly vital role in the process of endochondral bone formation. These important functions, the likely involvement of the PTH1R in certain genetic diseases affecting skeletal development and calcium homeostasis, and the potential utility of PTH in treating osteoporosis have been the driving force behind intense investigations of both the receptor and its peptide ligands. Recent lines of work have led to the identification of constitutively active PTH1Rs in patients with Jansen's metaphyseal chondrodysplasia, the demonstration of inverse agonism by certain ligand analogs, and the discovery of the PTH-2 receptor subtype that responds to PTH but not PTHrP. As reviewed herein, a detailed exploration of the receptor-ligand interaction process is currently being pursued through the use of site-directed mutagenesis and photoaffinity cross-linking methods; ultimately, such work could enable the dev...Continue Reading

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Citations

Oct 13, 2006·Annual Review of Pharmacology and Toxicology·Martine J SmitRob Leurs
Apr 7, 2009·The Journal of Biological Chemistry·William J McKinstryMichael W Parker
Jul 19, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Vandanajay BhatiaMiriam Falzon
Nov 26, 2015·Frontiers in Pharmacology·Kelly J CulhaneElsa C Y Yan
May 21, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Pedro M GuerreiroJ Larry Renfro
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R MizunoT Ohhashi
Jul 10, 2002·Current Opinion in Nephrology and Hypertension·Thorsten Vetter, Martin J Lohse
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Jul 12, 2018·American Journal of Physiology. Renal Physiology·Noriko IdeBeate Lanske
May 17, 2011·Protein Expression and Purification·Wang ChunxiaoBarbara Rasco
Jun 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Melika SaremV Prasad Shastri

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