Receptors for the age of anxiety: pharmacology of the benzodiazepines

Science
J F TallmanD W Gallager

Abstract

Investigation of the actions of the benzodiazepines has provided insights into the neurochemical mechanisms underlying anxiety, seizures, muscle relaxation, and sedation. Behavioral, electrophysical, pharmacological, and biochemical evidence indicates that the benzodiazepines exert their therapeutic effects by interacting with a high-affinity binding site (receptor) in the brain. The benzodiazepine receptor interacts with a receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter, and enhances its inhibitory effects. The benzodiazepine receptor may also interact with endogenous substances and several naturally occurring compounds, including the purines and nicotinamide, are candidates for this role. Both the purines and nicotinamide possess some benzodiazepine-like properties in vivo, although further work will be required to confirm their possible roles as endogenous benzodiazepines.

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Related Concepts

Nervousness
Nicotinamide Assay
Exertion
Anticonvulsants
Neural Inhibition
Anti-Anxiety Effect
Brain
Synaptic Transmission
Myopathy
Muscle Relaxation Phase

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