PMID: 6981839Jun 1, 1982Paper

Receptors for the third complement component on a proportion of large granular lymphocytes from human peripheral blood

Scandinavian Journal of Immunology
A NoceraM Ferrarini

Abstract

Large granular lymphocytes (LGL) are nonadherent cells with cytoplasmic azurophilic granules, avid receptors for the Fc portion of IgG, and a paranuclear localization of alpha-naphthyl acid esterase or acid phosphatase. LGL constitute the bulk of TG cells (cells with receptors for sheep erythrocytes and for IgG molecules) and null cells (non-T, non-B cells). In the present study we demonstrate that 20-33% of the circulating human LGL express receptors for the third complement component (C3R). When TG cell or null cell fractions from normal individuals or non-T cells from a patient with infantile agammaglobulinaemia (which contained almost exclusively LGL) were rosetted with erythrocytes coated with antibody and complement, a variable number of C3R-bearing cells were detected. Such cells were isolated and analysed further; the great majority of them displayed the cytochemical and ultrastructural features of LGL.

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Citations

Jan 1, 1989·Anatomy and Embryology·P Groscurth
Jan 1, 1983·Journal of Clinical Immunology·M FerrariniC E Grossi
Jan 1, 1989·Archives of Gynecology and Obstetrics·D ZaccheoC Martinoli
Jun 1, 1984·Clinical Immunology and Immunopathology·A EddyA Michael

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