PMID: 4895537Jun 1, 1969Paper

Recessive lethals: a new class of nonsense suppressors in Escherichia coli

Proceedings of the National Academy of Sciences of the United States of America
L Soll, P Berg

Abstract

Two new nonsense suppressors in Escherichia coli were found in partial diploids carrying F'14 and were shown to be on the episome. These suppressors can exist only in cells which also contain the su(-) allele, i.e., su(+)/su(-) heterozygotes. Presumably the mutations cause an alteration of an essential cellular component, the complete loss of which is lethal. Su7, an amber suppressor, has an efficiency of 76 per cent and su8, an ochre suppressor, an efficiency of 4 per cent.

References

Jan 1, 1966·Cold Spring Harbor Symposia on Quantitative Biology·J D SmithS Brenner
Feb 14, 1969·Journal of Molecular Biology·C W HillP Berg
Dec 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·D L EngelhardtN Zinder
Nov 1, 1965·Journal of Molecular Biology·E R SignerS Brenner
Nov 14, 1966·Journal of Molecular Biology·C Yanofsky, J Ito
Feb 26, 1960·Science·L GORINI, H KAUFMAN
Feb 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·A J CLARK, A D MARGULIES

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Citations

Mar 5, 1979·Molecular & General Genetics : MGG·M YarusL Soll
Jan 1, 1974·Molecular & General Genetics : MGG·J R Uomini, J R Roth
Jan 1, 1980·Molecular & General Genetics : MGG·L BreedenS Cline
Aug 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J L CampbellC C Richardson
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·R L White, M S Fox
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·W Yu, R J Spreitzer
Jun 1, 1975·Japanese Journal of Microbiology·T Aoi, I Watanabe
Jun 4, 2008·Annual Review of Biochemistry·Paul Berg
Apr 1, 1990·Idengaku zasshi·Z ChangH Ozeki
Oct 1, 1993·Trends in Genetics : TIG·L Guarente
Sep 28, 1970·Journal of Molecular Biology·C SquiresC W Hill
Apr 15, 1976·Journal of Molecular Biology·M C BrandrissD Botstein
Jun 5, 1980·Journal of Molecular Biology·R G KnowltonM Yarus
Jun 14, 1971·Journal of Molecular Biology·P Lu, A Rich
Jun 14, 1971·Journal of Molecular Biology·W R Folk, P Berg
Jul 14, 1971·Journal of Molecular Biology·C G Miller, J R Roth
Dec 8, 1988·Nature
Aug 4, 1971·Nature: New Biology·S J AustinJ G Scaife
Jun 7, 1972·Nature: New Biology·W R Folk, M Yaniv
Jan 1, 1972·Molecular & General Genetics : MGG·M UngerA Pfister
Feb 1, 1972·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·S L PhillipsH P Newton
Mar 1, 1976·Bacteriological Reviews·B J BachmannA L Taylor
May 1, 1971·Journal of Bacteriology·J GreebJ C Loper
Dec 1, 1972·Bacteriological Reviews·K B Low
Sep 1, 1974·Journal of Bacteriology·M J TevethiaM Mandel
Jun 1, 1983·Journal of Bacteriology·M Russel, P Model

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