PMID: 9663658Jul 15, 1998Paper

recessive spotting: a linked locus that interacts with W/Kit but is not allelic

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
D C BennettA Bernstein

Abstract

The murine coat-colour mutation recessive spotting (rs) maps very closely to the W/Kit locus, encoding the proto-oncoprotein Kit, the protein tyrosine kinase receptor for stem cell factor. Kit is important in the development of melanocytes, germ cells, interstitial cells of Cajal (ICC) and haemopoietic lineages, including mast cells. rs has never been genetically separated from Kit, and interacts with Kit mutations, suggesting that it is a recessive allele of Kit. Here we have tested this possibility. We have shown previously that diploid rs/rs melanocytes proliferated more slowly than did +/+ melanocytes, as did an immortal line of rs/rs melanocytes, melan-rs. The Kit mRNA level in rs/rs melanocytes was indistinguishable from that of other melanocyte lines. The Kit cDNA sequence from rs/rs melanocytes and the kinase activity of Kit in rs/rs mast cells appeared to be normal. No deficiency of mast cells or ICC was observed in rs/rs mice. Moreover, following the overexpression of a normal Kit cDNA, proliferation of rs/rs melanocytes was retarded further, but that of +/+ melanocytes was increased, indicating an intracellular interaction between rs and Kit. Of other closely linked tyrosine kinase genes, melanocytes and melanoblasts...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L LarueB Mintz
Sep 9, 1992·International Journal of Cancer. Journal International Du Cancer·P G NataliA Ullrich
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D A StephensonV M Chapman
Mar 15, 1987·International Journal of Cancer. Journal International Du Cancer·D C BennettI R Hart
Mar 15, 1994·International Journal of Cancer. Journal International Du Cancer·S MatteiM Herlyn
Jan 1, 1994·Critical Reviews in Oncogenesis·S LevY Yarden
Apr 1, 1995·Developmental Biology·M BućanC W Lo
Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·R DuttlingerP Besmer
Jan 3, 1995·International Journal of Cancer. Journal International Du Cancer·D J EastyD C Bennett
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·D L NagleM Bućan
Jan 1, 1993·International Review of Cytology·D C Bennett
Aug 1, 1995·Seminars in Immunology·R F Paulson, A Bernstein

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Citations

Nov 30, 2000·Melanoma Research·D J Easty, D C Bennett

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