Rechallenge of oxaliplatin-containing regimens in the third- or later-line therapy for patients with heavily treated metastatic colorectal cancer

OncoTargets and Therapy
Qiong YangDe-rong Xie

Abstract

The third- or later-line therapy available often yield poor survival benefit in patients metastatic colorectal cancer (mCRC). The retrospective study aimed to evaluate efficacy of rechallenge of oxaliplatin-containing regimens. Patients with mCRC who progressed from fluoropyrimidine, oxaliplatin, and irinotecan in the first- and second-line chemotherapy, were treated by reexposure to oxaliplatin-containing regimen. Patients treated by anti-epidermal growth factor receptor (EGFR) antibodies with irinotecan were included in the control arm. Ninety-five and 29 patients were treated with either oxaliplatin reexposure or anti-EGFR antibodies with irinotecan, respectively, as the third- or later-line therapy. The median time to treatment failure (TTF) and overall survival (OS) was 3.77 and 12.17 months in the oxaliplatin arm, with 4.77 months of TTF and 11.37 months of OS in the control arm; there was no significance between the 2 arms (p>0.05). Oxaliplatin reexposure resulted in 6.3% objective response rate with no complete response, 6 partial response, 39 stable disease, and 37 progressive disease. The disease control rate was 47.4% (45/95). The multivariate analysis found that patients who achieved disease control by oxaliplatin r...Continue Reading

Citations

Aug 9, 2020·Cancer Management and Research·Marissa LamEva Segelov
Dec 15, 2020·World Journal of Clinical Oncology·Tejaswini Parlapalle ReddyMaen Abdelrahim
Oct 23, 2020·Cancer Treatment Reviews·Gianluca MauriAndrea Sartore-Bianchi
May 15, 2021·BioMed Research International·Nihad CheragaNing-Ping Huang
Mar 9, 2020·Oncology Research and Treatment·Alexander SiebenhünerMarkus Borner

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