Recidivism Is the Leading Cause of Death Among Intravenous Drug Users Who Underwent Cardiac Surgery for Infective Endocarditis

Seminars in Thoracic and Cardiovascular Surgery
Max Jordan Nguemeni TiakoArnar Geirsson

Abstract

The proportional incidence of intravenous drug use (IVDU)-associated infective endocarditis (IE) cases requiring surgery has increased significantly, mirroring the national opioid crisis. Recidivism is common but its impact on postoperative outcomes is unclear. We aimed to evaluate short- and mid-term postoperative outcomes associated with recidivism in this population. We retrospectively reviewed 180 consecutive patients (54 IVDU and 126 non-IVDU) surgically treated for IE from 2011 to 2016. The institutional database was linked to the Connecticut Department of Public Health Death Index to capture statewide long-term mortality and causes of death. Regression models were fitted to evaluate the association between IVDU status and perioperative adverse events, mid-term survival, and causes of death. IVDU patients were younger and had fewer comorbidities. Diabetes, hypertension, peripheral vascular disease, and previous coronary artery bypass graft were less frequently present in IVDU patients compared to non-IVDU patients (P < 0.05 for all). The Society of Thoracic Surgeons mortality prediction score for IE was lower in IVDU patients (22.9 vs 33.6, P < 0.001). IVDU was associated with a significantly increased risk of perioperati...Continue Reading

Citations

Dec 31, 2019·Interactive Cardiovascular and Thoracic Surgery·Vilem RohnFrantisek Mosna
Aug 26, 2020·Journal of Cardiac Surgery·Arman KilicThomas G Gleason
May 6, 2020·International Journal of Legal Medicine·Federico ManettiStefano D'Errico
Sep 5, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David P SerotaHansel E Tookes
Jan 15, 2021·Scientific Reports·Allan ClarelinSigurdur Ragnarsson
Feb 5, 2021·Journal of the American College of Cardiology·Juan M PericàsUNKNOWN International Collaboration on Endocarditis (ICE) Investigators
Aug 13, 2020·Infectious Disease Clinics of North America·Asher Schranz, Joshua A Barocas
Aug 13, 2020·Infectious Disease Clinics of North America·David P SerotaMarcos C Schechter
Apr 28, 2021·Infectious Diseases·Gregory J SinnerSteve W Leung
May 27, 2021·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Max Jordan Nguemeni TiakoMelissa B Weimer
May 7, 2021·Journal of the American Heart Association·Sami El-DalatiGeorge Michael Deeb
Jun 28, 2021·The Thoracic and Cardiovascular Surgeon·Antti HuuskonenPeter Raivio
Nov 11, 2020·Seminars in Thoracic and Cardiovascular Surgery·Sameer HirjiTsuyoshi Kaneko
Dec 7, 2020·Seminars in Thoracic and Cardiovascular Surgery·Max Jordan Nguemeni TiakoMelissa B Weimer
Feb 5, 2022·Anesthesiology·Henning HermannsBenedikt Preckel

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