Recipient tissue factor expression is associated with consumptive coagulopathy in pig-to-primate kidney xenotransplantation.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
C C LinD K C Cooper

Abstract

Consumptive coagulopathy (CC) remains a challenge in pig-to-primate organ xenotransplantation (Tx). This study investigated the role of tissue factor (TF) expression on circulating platelets and peripheral blood mononuclear cells (PBMCs). Baboons (n = 9) received a kidney graft from pigs that were either wild-type (n = 2), alpha1,3-galactosyltransferase gene-knockout (GT-KO; n = 1) or GT-KO and transgenic for the complement-regulatory protein, CD46 (GT-KO/CD46, n = 6). In the baboon where the graft developed hyperacute rejection (n = 1), the platelets and PBMCs expressed TF within 4 h of Tx. In the remaining baboons, TF was detected on platelets on post-Tx day 1. Subsequently, platelet-leukocyte aggregation developed with formation of thrombin. In the six baboons with CC, TF was not detected on baboon PBMCs until CC was beginning to develop. Graft histopathology showed fibrin deposition and platelet aggregation (n = 6), but with only minor or no features indicating a humoral immune response (n = 3), and no macrophage, B or T cell infiltration (n = 6). Activation of platelets to express TF was associated with the initiation of CC, whereas TF expression on PBMCs was concomitant with the onset of CC, often in the relative absence ...Continue Reading

References

Sep 1, 1995·Nature Medicine·F H BachW W Hancock
Oct 1, 1994·Immunological Reviews·F H BachW W Hancock
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·P L GiesenY Nemerson
Dec 21, 2002·Science·Carol J PhelpsDavid L Ayares
Jun 18, 2003·Transplantation·Bernd GollacknerJay A Fishman
Oct 3, 2003·Cardiovascular Research·Tymen T KellerEric C M van Gorp
May 1, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nigel Mackman
Jul 29, 2005·Journal of the American Society of Nephrology : JASN·Akira ShimizuRobert B Colvin
Oct 25, 2006·The Journal of Experimental Medicine·Hansjörg SchwertzAndrew S Weyrich
Nov 18, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·E CantuR D Davis
Mar 10, 2007·Blood·Olga PanesDiego Mezzano
Jun 15, 2007·Journal of Thrombosis and Haemostasis : JTH·D M Monroe, N S Key
Nov 23, 2007·Journal of Leukocyte Biology·Marcel SchoutenTom van der Poll
Dec 20, 2007·Journal of Thrombosis and Haemostasis : JTH·N Mackman
Jan 17, 2008·Journal of Leukocyte Biology·Nailin Li
Sep 4, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Hidetaka HaraDavid K C Cooper
Sep 20, 2008·The Journal of Clinical Investigation·Patricia RedechaGuillermina Girardi
Aug 12, 2009·The Journal of Experimental Medicine·Grace M ThomasChristophe Dubois

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Citations

Mar 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mohammad A KhanMark R Nicolls
Mar 19, 2011·Current Opinion in Organ Transplantation·Burcin EkserDavid K C Cooper
Mar 19, 2011·Current Opinion in Organ Transplantation·Peter J CowanAnthony J F d'Apice
Oct 20, 2012·Expert Review of Clinical Immunology·Burcin EkserDavid Kc Cooper
Nov 10, 2015·Expert Review of Clinical Immunology·David Kc Cooper, Rita Bottino
Jan 28, 2016·Xenotransplantation·David K C CooperRita Bottino
Jan 21, 2016·The Annals of Thoracic Surgery·Raghav MurthyDavid K C Cooper
Oct 4, 2013·Kidney International·Peter J CowanAnthony J F d'Apice
Sep 15, 2015·The Journal of Pathology·David K C CooperDavid Ayares
Jul 26, 2015·International Journal of Surgery·Mohamed B Ezzelarab, David K C Cooper
Jul 30, 2015·International Journal of Surgery·Peter J Cowan, Simon C Robson
Jul 15, 2015·International Journal of Surgery·David K C CooperA Joseph Tector
Aug 26, 2015·International Journal of Surgery·Hayato Iwase, Takaaki Kobayashi
Jun 12, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·K F E LeeH Gock
Aug 23, 2012·Xenotransplantation·Hayato IwaseMohamed B Ezzelarab
Dec 16, 2011·Xenotransplantation·Mohamed EzzelarabDavid K C Cooper
Sep 14, 2012·Xenotransplantation·Corin EzzelarabMohamed B Ezzelarab
Aug 8, 2014·Xenotransplantation·Guerard W ByrneChristopher G A McGregor
May 31, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Burcin EkserBruno Gridelli
Aug 19, 2011·Xenotransplantation·Andreas BauerFrank Christ
Aug 22, 2015·Xenotransplantation·Hayato IwaseDavid K C Cooper
Jul 8, 2014·The Journal of Thoracic and Cardiovascular Surgery·Muhammad M MohiuddinKeith A Horvath
Sep 12, 2014·Xenotransplantation·Mohamed B EzzelarabDavid K Cooper
Oct 31, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Magdalena BoksaDaniel Lipiński
Oct 25, 2011·Lancet·Burcin EkserDavid K C Cooper
Mar 16, 2017·Xenotransplantation·Hayato IwaseMohamed B Ezzelarab
Jul 26, 2018·Artificial Organs·Doris A TaylorLuiz C Sampaio
Jan 1, 2019·Transplant International : Official Journal of the European Society for Organ Transplantation·Wolf RamackersAndreas Tiede
Mar 10, 2012·Radiation Research·Dominick J O McIntyreJohn R Griffiths
Jun 19, 2012·Xenotransplantation·David K C CooperRichard N Pierson

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