Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells

Nature
Estelle BettelliVijay K Kuchroo

Abstract

On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are traditionally thought to differentiate into T(H)1 and T(H)2 cell subsets. T(H)1 cells are necessary to clear intracellular pathogens and T(H)2 cells are important for clearing extracellular organisms. Recently, a subset of interleukin (IL)-17-producing T (T(H)17) cells distinct from T(H)1 or T(H)2 cells has been described and shown to have a crucial role in the induction of autoimmune tissue injury. In contrast, CD4+CD25+Foxp3+ regulatory T (T(reg)) cells inhibit autoimmunity and protect against tissue injury. Transforming growth factor-beta (TGF-beta) is a critical differentiation factor for the generation of T(reg) cells. Here we show, using mice with a reporter introduced into the endogenous Foxp3 locus, that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ T(reg) cells induced by TGF-beta. We also demonstrate that IL-23 is not the differentiation factor for the generation of T(H)17 cells. Instead, IL-6 and TGF-beta together induce the differentiation of pathogenic T(H)17 cells from naive T cells. Our data demonstrate a dichoto...Continue Reading

References

Sep 1, 1988·Immunology Today·K Bottomly
Mar 20, 1998·International Reviews of Immunology·T Hirano
Mar 22, 2002·Nature Reviews. Immunology·Leonid Gorelik, Richard A Flavell
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christi ParhamKevin W Moore
Nov 6, 2002·The Journal of Biological Chemistry·Sudeepta AggarwalAustin L Gurney
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell
May 7, 2003·The Journal of Experimental Medicine·Estelle BettelliVijay K Kuchroo
Jan 20, 2005·The Journal of Experimental Medicine·Claire L LangrishDaniel J Cua

❮ Previous
Next ❯

Citations

Oct 11, 2007·Inflammatory Bowel Diseases·Nanna Ny KristensenMogens Helweg Claesson
Mar 15, 2008·Inflammatory Bowel Diseases·Jeffrey B BrownTerrence A Barrett
May 31, 2008·Inflammatory Bowel Diseases·Veera HölttäOuti Vaarala
May 31, 2008·Inflammatory Bowel Diseases·Bi-Feng QianR Balfour Sartor
Oct 8, 2008·Inflammatory Bowel Diseases·Marta LlopisJuan-R Malagelada
Mar 3, 2009·Inflammatory Bowel Diseases·Clara Abraham, Judy Cho
Mar 27, 2009·Inflammatory Bowel Diseases·Bobby J Cherayil
Mar 12, 2010·Inflammatory Bowel Diseases·Massimiliano SarraGiovanni Monteleone
Feb 15, 2011·Inflammatory Bowel Diseases·Alexandra I Thompson, Charlie W Lees
Mar 8, 2011·Inflammatory Bowel Diseases·Gheorghe HundorfeanJonas Mudter
Oct 14, 2011·Inflammatory Bowel Diseases·J VerdierF M Ruemmele
Nov 24, 2006·Internal and Emergency Medicine·Sergio Romagnani
Feb 17, 2009·Archivum Immunologiae Et Therapiae Experimentalis·Byung Ha LeeCuong Q Nguyen
Jan 6, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Guangjie Chen
Oct 6, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Jacek R Wilczyński, Markus Duechler
Mar 30, 2011·Archivum Immunologiae Et Therapiae Experimentalis·Johannes StephaniJan Hendrik Niess
Feb 16, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Qing WangJianying Zhou
Aug 24, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Hae-Ran ParkUhee Jung
Sep 22, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Ruijun LiuChunsheng Wang
May 15, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Huang-Pin WuYu-Chih Liu
Apr 25, 2009·Cellular and Molecular Life Sciences : CMLS·Creg J WorkmanDario A A Vignali
Apr 7, 2012·Cellular and Molecular Life Sciences : CMLS·Hidehiro Yamane, William E Paul
Jul 22, 2006·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Bernhard Homey
Jun 15, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Gurumoorthy KrishnamoorthyHartmut Wekerle
Dec 8, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela PaclikAndreas Sturm
Dec 31, 2010·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wei YangZhihai Qin
Oct 16, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Junpeng WangDayong Wu
Mar 31, 2010·Cancer Immunology, Immunotherapy : CII·Yuqiang Ji, Wanggang Zhang
Jun 22, 2011·Cancer Immunology, Immunotherapy : CII·Takao MiyabayashiIchiei Narita
Jul 9, 2011·Cancer Immunology, Immunotherapy : CII·Anna Maria BerghellaIda Contasta
Jul 23, 2011·Cancer Immunology, Immunotherapy : CII·Gabriele CantiniSerena Pellegatta
Nov 17, 2011·Cancer Immunology, Immunotherapy : CII·Gary W MiddletonHardev S Pandha
Jul 4, 2012·Cancer Immunology, Immunotherapy : CII·Manjeera PaladuguPrahlad Parajuli
May 26, 2011·Seminars in Immunopathology·Antonella SistiguLaurence Zitvogel
Oct 26, 2012·Seminars in Immunopathology·Bridget M LarkinMiguel J Stadecker
Nov 20, 2012·Seminars in Immunopathology·Sergei I Grivennikov
Aug 29, 2013·Seminars in Immunopathology·Nam Trung NguyenTadamitsu Kishimoto
Aug 3, 2011·Rheumatology International·Qian NiuLan-lan Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.