PMID: 2105268Feb 1, 1990Paper

Reciprocal effects of dexamethasone on vasodilatory responses to arachidonic acid and prostanoids in the isolated perfused rabbit kidney

Hypertension
W C SessaA Nasjletti

Abstract

We reported that dexamethasone treatment of rabbits causes a reduction in renal vasoconstrictor responses to prostaglandin F2 alpha and U46619, an agonist at the thromboxane-endoperoxide receptor, but not to phenylephrine. The purpose of this study was to examine if dexamethasone treatment can affect the renal vasodilatory responses to prostacyclin (PGI2) and prostaglandin E2 (PGE2) in isolated Krebs-perfused kidneys constricted with phenylephrine. In kidneys from dexamethasone-treated rabbits, the vasodilatory response to PGI2 was reduced by 57%, whereas that to PGE2 was converted to a vasoconstrictor response. This effect of dexamethasone appears to be specific in that the renal vasodilatory responses to forskolin and to sodium nitroprusside were not affected by the steroid. Contrasting with the inhibitory effect of dexamethasone on prostanoid-induced renal vasodilation, treatment with dexamethasone augmented the renal vasodilatory response to arachidonic acid; for example, arachidonic acid, at 10 micrograms decreased perfusion pressure by 24.8 +/- 5.4 and 49.0 +/- 5.6 mm Hg in kidneys from vehicle- and dexamethasone-treated rabbits, respectively. The enhanced vasodilatory effect of arachidonic acid could not be attributed to...Continue Reading

References

Feb 1, 1975·The American Journal of Physiology·L R KrakoffE Sutter
Apr 1, 1988·The American Journal of the Medical Sciences·R A JohnsM J Peach
Aug 1, 1986·Clinical and Experimental Pharmacology & Physiology·M J MillerJ C McGiff
Aug 1, 1985·Prostaglandins, Leukotrienes, and Medicine·A Naray-Fejes-Toth, G Fejes-Toth

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Citations

Jul 3, 2002·The Journal of Clinical Investigation·Zhonghua QiMatthew D Breyer
Aug 14, 2012·Phytotherapy Research : PTR·Jackie Yan-Yan ChanShun-Wan Chan
Jul 1, 1992·British Journal of Pharmacology·A AhluwaliaR J Flower

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