Reciprocal expression of two candidate di-iron enzymes affecting photosystem I and light-harvesting complex accumulation

The Plant Cell
Jeffrey L MoseleySabeeha S Merchant

Abstract

Crd1 (Copper response defect 1), which is required for the maintenance of photosystem I and its associated light-harvesting complexes in copper-deficient (-Cu) and oxygen-deficient (-O(2)) Chlamydomonas reinhardtii cells, is localized to the thylakoid membrane. A related protein, Cth1 (Copper target homolog 1), is shown to have a similar but not identical function by genetic suppressor analysis of gain-of-function sct1 (suppressor of copper target 1) strains that are transposon-containing alleles at CTH1. The pattern of Crd1 versus Cth1 accumulation is reciprocal; Crd1 abundance is increased in -Cu or -O(2) cells, whereas Cth1 accumulates in copper-sufficient (+Cu), oxygenated cells. This expression pattern is determined by a single trans-acting regulatory locus, CRR1 (COPPER RESPONSE REGULATOR 1), which activates transcription in -Cu cells. In +Cu cells, a 2.1-kb Cth1 mRNA is produced and translated, whereas Crd1 is transcribed only at basal levels, leading to Cth1 accumulation in +Cu cells. In -Cu cells, CRR1 function determines the activation of Crd1 expression and the production of an alternative 3.1-kb Cth1 mRNA that is extended at the 5' end relative to the 2.1-kb mRNA. Synthesis of the 3.1-kb mRNA, which encodes six smal...Continue Reading

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Citations

Sep 7, 2005·Photosynthesis Research·Zinaida VasileuskayaChristoph F Beck
Mar 21, 2007·Photosynthesis Research·David W Bollivar
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mark E CorkinsAmanda J Bird
Jul 10, 2009·The Journal of Biological Chemistry·Aimee M TerauchiSabeeha S Merchant
Oct 16, 2012·Molecular & Cellular Proteomics : MCP·Scott I HsiehJoseph A Loo
May 6, 2008·Molecular & Cellular Proteomics : MCP·Wojciech MajeranKlaas J van Wijk
Mar 2, 2010·Molecular & Cellular Proteomics : MCP·Mia TerashimaMichael Hippler
Dec 18, 2002·The EMBO Journal·Jeffrey L MoseleyMichael Hippler
Dec 11, 2008·Photochemistry and Photobiology·Michael D AllenSabeeha S Merchant
Feb 12, 2013·Applied and Environmental Microbiology·Ekaterina N Boldareva-NuianzinaMichal Koblízek
Apr 7, 2009·Journal of Bacteriology·Kuo-Hsiang TangRobert E Blankenship
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Apr 17, 2007·Current Opinion in Plant Biology·Jean-François BriatFrédéric Gaymard

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