Sep 1, 1975

Reciprocal influence of the graft vs. host reaction and pregnancy

Biulleten' eksperimental'noĭ biologii i meditsiny
V S DukovaE A Fedosov

Abstract

The graft versus host reaction (GVHR) was induced in mouse females-hybrids F1 (CBA X C57BL/6) by intravenous injection of suspension of the lymphoid cells of the spleen and of lymphoid nodes from C57BL/6 mouse females. Pregnancy resulted from interbreeding of the test females with syngenic males 1--5 days before, and 1--10, 10--20, 30--40 and more than 40 days after the moment of the lymphoid cells injection, aggravated the GVHR induced transplantation disease. At the same time the GVHR under these conditions decreased the percentage of pregnant animals and brought to child-bearing disfunction of the test animals (stillbirth, death of pregnant females, miscarriage). In some of the test mice aggravation of the GVHR was observed after delivery. Survival of the progeny decreased.

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Mentioned in this Paper

Mice, Inbred C57BL
Pregnancy Complications
Graft Vs Host Reaction

About this Paper

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