Reciprocal interaction between striatal cholinergic and low-threshold spiking interneurons - A computational study.

The European Journal of Neuroscience
Johanna Frost NylénJeanette Hellgren Kotaleski

Abstract

The striatum is the main input stage of the basal ganglia receiving extrinsic input from cortex and thalamus. The striatal projection neurons (SPN) constitute 95% of the neurons in the striatum in mice while the remaining 5% are cholinergic and GABAergic interneurons. The cholinergic (ChIN) and low-threshold spiking interneurons (LTS) are spontaneously active and form a striatal subnetwork involved in salience detection and goal-directed learning. Activation of ChINs has been shown to inhibit LTS via muscarinic receptor type 4 (M4R) and LTS in turn can modulate ChINs via nitric oxide (NO) causing a prolonged depolarization. Thalamic input prefentially excites ChINs, whereas input from motor cortex favours LTS, but can also excite ChINs. This varying extrinsic input with intrinsic reciprocal, yet opposing, effects raises the possibility of a slow input-dependent modulatory subnetwork. Here, we simulate this subnetwork using multicompartmental neuron models that incorporate data regarding known ion channels and detailed morphological reconstructions. The modelled connections replicate the experimental data on muscarinic (M4R) and nitric oxide modulation onto LTS and ChIN, respectively, and capture their physiological interaction....Continue Reading

References

May 1, 1979·The Journal of Physiology·A Dutton, R E Dyball
Jan 1, 1988·Annual Review of Pharmacology and Toxicology·T BartfaiP Serfözö
Dec 1, 1995·Trends in Neurosciences·Y KawaguchiP C Emson
Oct 3, 1998·The European Journal of Neuroscience·P CalabresiG Bernardi
Aug 11, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·M L Hines, N T Carnevale
Jul 9, 2002·The European Journal of Neuroscience·Diego CentonzePaolo Calabresi
Sep 30, 2003·Reviews in the Neurosciences·Diego CentonzePaolo Calabresi
Feb 27, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony R West, Anthony A Grace
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolas MauriceD James Surmeier
Aug 12, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Weixing ShenD James Surmeier
Jan 12, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Pavel Pakhotin, Enrico Bracci
Jan 20, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Madoka NarushimaMasanobu Kano
Mar 29, 2008·The European Journal of Neuroscience·Janie M OndracekAnthony R West
Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
Aug 26, 2009·Journal of Molecular and Cellular Cardiology·Justus M B Anumonwo, Anatoli N Lopatin
Oct 6, 2009·Journal of Neurochemistry·Diana J Park, Anthony R West
Feb 22, 2011·Current Opinion in Neurobiology·Talia N Lerner, Anatol C Kreitzer
Aug 9, 2013·Journal of Neurophysiology·Sarah L HawesKim T Blackwell
Feb 18, 2014·ACS Chemical Neuroscience·Tristano PancaniZixiu Xiang
Jun 23, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Marc Deffains, Hagai Bergman
Oct 10, 2015·Cell·Henry MarkramFelix Schürmann
Oct 16, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anu G NairJeanette Hellgren Kotaleski
Dec 5, 2015·Frontiers in Cellular Neuroscience·Craig P BlomeleyEnrico Bracci
May 21, 2016·Frontiers in Cellular Neuroscience·Rasha ElghabaEnrico Bracci
Jun 13, 2017·Nature Communications·Maxime AssousJames M Tepper
Aug 10, 2017·Journal of Neurochemistry·Juhee Haam, Jerrel L Yakel
Aug 23, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kai DuJeanette Hellgren Kotaleski
Oct 13, 2017·Neuron·Dennis A BurkeVeronica A Alvarez
Jan 24, 2018·The European Journal of Neuroscience·Kyuhyun ChoiMarc V Fuccillo
Feb 27, 2018·The European Journal of Neuroscience·Maxime Assous, James M Tepper
Mar 31, 2018·The European Journal of Neuroscience·Kim T BlackwellDavid M Lovinger
May 24, 2018·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maxime AssousJames M Tepper

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Citations

Mar 25, 2021·The European Journal of Neuroscience·Yoland SmithThomas Boraud
Jul 25, 2021·Current Biology : CB·Elizabeth N HollyMarc V Fuccillo
Nov 9, 2021·Frontiers in Neural Circuits·Johanna Frost NylenJeanette Hellgren Kotaleski

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