Reciprocal Interactions between Medial Septum and Hippocampus in Theta Generation: Granger Causality Decomposition of Mixed Spike-Field Recordings

Frontiers in Neuroanatomy
Daesung KangBernat Kocsis

Abstract

The medial septum (MS) plays an essential role in rhythmogenesis in the hippocampus (HIPP); theta-rhythmic bursts of MS neurons are believed to drive theta oscillations in rats' HIPP. The MS theta pacemaker hypothesis has solid foundation but the MS-hippocampal interactions during different behavioral states are poorly understood. The MS and the HIPP have reciprocal connections and it is not clear in particular what role, if any, the strong HIPP to MS projection plays in theta generation. To study the functional interactions between MS and HIPP during different behavioral states, this study investigated the relationship between MS single-unit activity and HIPP field potential oscillations during theta states of active waking and REM sleep and non-theta states of slow wave sleep (SWS) and quiet waking (QW), i.e., sleep-wake states that comprise the full behavioral repertoire of undisturbed, freely moving rats. We used non-parametric Granger causality (GC) to decompose the MS-HIPP synchrony into its directional components, MS→HIPP and HIPP→MS, and to examine the causal interactions between them within the theta frequency band. We found a significant unidirectional MS→HIPP influence in non-theta states which switches to bidirectio...Continue Reading

References

Jan 1, 1986·Progress in Neurobiology·B H Bland
Jun 9, 1987·Brain Research·A AlonsoE García-Austt
Apr 1, 1969·Electroencephalography and Clinical Neurophysiology·C H Vanderwolf
Jun 1, 1966·Brain : a Journal of Neurology·G Raisman
Dec 1, 1996·Neuroscience·M SerafinM Mühlethaler
Jan 19, 2000·Journal of Neuroscience Methods·K Sameshima, L A Baccalá
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·E E FanselowM A Nicolelis
Feb 8, 2002·Neuron·György Buzsáki
Aug 3, 2002·Nature Reviews. Neuroscience·Edward F Pace-Schott, J Allan Hobson
Mar 15, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mihály HajósEva Hajós-Korcsok
Sep 27, 2003·Neural Computation·Liqiang ZhuJiping He
Oct 29, 2005·The Journal of Comparative Neurology·Clifford B SaperThomas E Scammell
Jun 15, 2007·Brain Research Bulletin·Takayoshi Masuoka, Chiaki Kamei
Aug 19, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shozo JinnoPeter Somogyi
Oct 18, 2007·The Journal of Pharmacology and Experimental Therapeutics·M HajósB Kocsis
Feb 1, 2008·Physical Review Letters·Mukeshwar DhamalaMingzhou Ding
Apr 9, 2008·NeuroImage·Mukeshwar DhamalaMingzhou Ding
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Frédéric ManseauSylvain Williams
Jan 13, 2009·Journal of Computational Neuroscience·Aatira G NedungadiMingzhou Ding
Jun 26, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Balázs HangyaViktor Varga
Apr 2, 2011·PLoS Computational Biology·Sanggyun KimEmery N Brown
Jan 22, 2013·ACS Chemical Neuroscience·Susanna LyBernat Kocsis
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Marie VandecasteeleGyörgy Buzsáki
Jun 5, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Holger DannenbergHeinz Beck
Feb 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Bowon KimJee Hyun Choi

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Citations

Dec 10, 2017·Brain Structure & Function·Bernat KocsisAlexis Roy
Nov 21, 2019·Scientific Reports·Víctor J López-MadronaErnesto Pereda
Jun 15, 2019·The Journal of Comparative Neurology·Debora BuenoMartin Metzger
Jan 28, 2021·Brain : a Journal of Neurology·Yuichi TakeuchiAntal Berényi
Jan 20, 2020·Neuroscience Research·Yuichi Takeuchi, Antal Berényi
May 3, 2021·Neuropharmacology·Joanne C Damborsky, Jerrel L Yakel
Jul 27, 2021·Frontiers in Neural Circuits·Yuichi TakeuchiAntal Berényi
Nov 20, 2019·Epilepsy & Behavior : E&B·Renan Augusto Viana MendesCleiton Lopes-Aguiar

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Software Mentioned

Spike2
MATLAB

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