Reciprocal relationships between general (Propofol) anesthesia and circadian time in rats

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Etienne ChalletLaure Pain

Abstract

Several common postdischarge symptoms, such as sleep disorders, headache, drowsiness or general malaise, evoke disturbances of circadian rhythms due to jet lag (ie crossing time zones) or shift work rotation. Considering that general anesthesia is associated with numerous effects on the central nervous system, we hypothesized that it may also act on the circadian timing system. We first determined the effects of the circadian timing on general anesthesia. We observed that identical doses of propofol showed marked circadian fluctuations in duration of effects, with a peak at the middle of the resting period (ie 7 h after lights on). Then, we examined the effects of general anesthesia on circadian timing, by analysing stable free-running circadian rhythms (ie in constant environmental conditions), an experimental approach used widely in circadian biology. Free-running rats were housed in constant darkness and temperature to assess possible phase-shifting effects of propofol anesthesia according to the time of the day. When administered around (+/-2 h) the daily rest/activity transition point, a 30-min propofol anesthesia induced a 1-h phase advance in the free-running rest-activity rhythm, while anesthesia had no significant rese...Continue Reading

References

Jul 1, 1995·Frontiers in Neuroendocrinology·F W TurekJ S Takahashi
Nov 24, 1995·Neuroscience Letters·B I KanterewiczD P Cardinali
Jun 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·F PrudianB Bruguerolle
Nov 11, 1998·Acta Anaesthesiologica Scandinavica·A ReberM Schneider
Feb 24, 2001·Psychiatry and Clinical Neurosciences·M OzoneY Tanifuji
Mar 21, 2002·Acta Anaesthesiologica Scandinavica·J KärkeläM Pasanen
Apr 20, 2002·Anesthesiology·Christopher L WuLee A Fleisher
Apr 26, 2002·Anesthesia and Analgesia·Xiangyang GuoAlain Vuylsteke
Jul 12, 2002·Cell and Tissue Research·Martha U Gillette, Jennifer W Mitchell
Oct 10, 2002·Current Biology : CB·Steven A BrownUeli Schibler
Mar 8, 2003·Journal of Neuroendocrinology·P Pévet
Mar 28, 2003·Journal of Neurophysiology·Erik D Herzog, Rachel M Huckfeldt
Apr 18, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Etienne Challet, Paul Pévet
Jun 19, 2003·Anesthesiology Clinics of North America·Nina Deutsch, Christopher L Wu
Jan 24, 2004·Anesthesiology·Dominique Chassard, Bernard Bruguerolle
May 18, 2004·Sleep Medicine Reviews·Avery Tung, Wallace B Mendelson
Aug 18, 2004·Sleep Medicine Reviews·I Haimov, J Arendt
Oct 6, 2004·Best Practice & Research. Clinical Anaesthesiology·Anil Gupta

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Citations

Jun 15, 2010·Journal of Pharmacokinetics and Pharmacodynamics·Agnieszka BienertMiłosz Regulski
Nov 26, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jibran Y Khokhar, Rachel F Tyndale
Apr 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·James F CheesemanGuy R Warman
Jun 7, 2014·Pharmacological Reports : PR·Agnieszka BienertEdmund Grześkowiak
May 5, 2007·Current Opinion in Anaesthesiology·Dominique ChassardEmmanuel Boselli
Dec 2, 2009·IET Systems Biology·R MoriokaK Horimoto
Jan 6, 2016·Chronobiology International·Nicola M LudinGuy R Warman
Jul 6, 2010·Annales Françaises D'anesthèsie Et De Rèanimation·G DispersynL Pain
May 27, 2008·Sleep Medicine Reviews·Xavier DrouotLaurent Brochard
Sep 23, 2011·Chronobiology International·Anisoara C N JardimGuy R Warman
Jan 26, 2010·Anesthesiology·Garance DispersynYvan Touitou
Jul 24, 2018·Chronobiology International·Nawfel Ben-HamoudaLaure Pain
Apr 9, 2013·Pharmacological Reports : PR·Agnieszka BienertEdmund Grześkowiak
Nov 14, 2008·Chronobiology International·Garance DispersynYvan Touitou
Oct 22, 2020·Chronobiology International·Binwen LiuTianjiao Xia
Oct 1, 2018·Experimental Neurology·Alma Orts-SebastianGuy R Warman
Feb 7, 2017·Sleep Medicine Reviews·Raewyn C PoulsenJames F Cheeseman
Dec 29, 2020·Biochemical Pharmacology·Gratia Nguyen, Svetlana Postnova

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