Reciprocal repression between TUSC7 and miR-23b in gastric cancer

International Journal of Cancer. Journal International Du Cancer
Peng QiXiang Du

Abstract

Recently, long noncoding RNAs (lncRNAs) were demonstrated to play important regulatory roles in biological processes and cancer biology. However, the overall pathophysiological contribution of lncRNAs to gastric cancer (GC) remains largely unknown. In this study, differentially expressed lncRNAs in GC and paired adjacent normal tissue samples were identified by microarray and were validated using quantitative real-time polymerase chain reaction (qRT-PCR). One particular lncRNA, tumour suppressor candidate 7 (TUSC7), was analyzed in sequential large cohorts, and the Kaplan-Meier method with the log-rank test for comparisons was used to analyse the survival data. The results indicated that TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients. Applying loss-of-function and gain-of-function approaches, we determined that TUSC7 suppressed tumour cell growth in vitro and in vivo. Furthermore, we showed that TUSC7 was a direct transcriptional target of p53 via interaction of p53 with the putative p53-response element in the upstream region of TUSC7. Finally, we demonstrated reciprocal repression between TUSC7 and miR-23b; in ...Continue Reading

References

Apr 30, 2002·Seminars in Radiation Oncology·Wa'el El-Rifai, Steven M Powell
Mar 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Peggy S EisJames E Dahlberg
Jun 2, 2007·Molecular Cell·Tsung-Cheng ChangJoshua T Mendell
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fedor V KarginovGregory J Hannon
Apr 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Fabio FarinatiMassimo Rugge
Apr 24, 2008·Nature Reviews. Molecular Cell Biology·Todd RileyArnold Levine
Feb 10, 2009·Proceedings of the National Academy of Sciences of the United States of America·Mohit SachdevaYin-Yuan Mo
Apr 25, 2009·PLoS Genetics·John S Mattick
Sep 25, 2009·Nature Reviews. Cancer·Daniel MenendezMichael A Resnick
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Zhaohui HuangXiang Du
Apr 2, 2010·Current Opinion in Cell Biology·Ling-Ling Chen, Gordon G Carmichael
May 22, 2010·Cancer Letters·William K K WuJoseph J Y Sung
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Aug 24, 2010·Human Molecular Genetics·Maite Huarte, John L Rinn
Jan 22, 2011·World Journal of Gastroenterology : WJG·Stefania NobiliGabriella Nesi
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Jul 20, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu YangShu-han Sun
Apr 25, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Eric SteckWiltrud Richter
Jun 6, 2012·Annual Review of Biochemistry·John L Rinn, Howard Y Chang
Jul 28, 2012·Expert Opinion on Therapeutic Targets·Andrew S GiraudLouise M Judd
Sep 11, 2012·Advances in Pharmacology·Khaldoun Almhanna
Sep 22, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Peng Qi, Xiang Du
Nov 13, 2012·Journal of Cancer Research and Clinical Oncology·Feng YangGuoen Fang
Feb 13, 2013·BMC Medical Genomics·Liran JuanYunlong Liu
Apr 6, 2013·Nucleic Acids Research·Qian LiuYin-Yuan Mo
May 7, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiliang SunJunming Guo
May 18, 2013·Journal of Translational Medicine·Peng QiXiang Du
Jul 13, 2013·International Journal of Biological Sciences·Zhi-Yuan XuXiang-Dong Cheng
Aug 30, 2013·Scientific Reports·Eleonora LeucciAnders H Lund
Sep 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming SunXianghua Liu
Dec 12, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qifeng WangXiang Du

❮ Previous
Next ❯

Citations

Mar 16, 2016·International Journal of Molecular Sciences·Ahmed S BayoumiIl-Man Kim
Mar 24, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yufeng WangCheng Guo
Sep 26, 2015·Briefings in Functional Genomics·Ye HuJing-Yuan Fang
May 18, 2016·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Xing-Dong XiongJin-Ming Yang
Jul 29, 2016·Cellular and Molecular Life Sciences : CMLS·Jun TieDaiming Fan
Oct 22, 2016·Frontiers in Cellular Neuroscience·Chao ShangYi-Xue Xue
Feb 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jian XuJian Zhao
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chao ShangLirong Meng
Feb 6, 2018·Cancer Chemotherapy and Pharmacology·Chao ShangYang Hong
Jun 21, 2017·Journal of Cellular and Molecular Medicine·Weiwei WengXiang Du
Aug 11, 2016·F1000Research·Andrew FeslerJingfang Ju
Oct 28, 2019·Bioscience Reports·Menglin Cong, Rui Jing
Jan 21, 2016·Oncotarget·Tianwen LiJunming Guo
Oct 27, 2015·World Journal of Gastroenterology : WJG·Qing YangLei Ding
Apr 29, 2016·Briefings in Functional Genomics·Mojdeh Nasrollahzadeh-KhakianiParvaneh Nikpour
Aug 23, 2016·World Journal of Gastroenterology : WJG·Meng Zhang, Xiang Du
Mar 27, 2018·Journal of Cellular Physiology·Na LiWei Li
Mar 14, 2018·Journal of Experimental & Clinical Cancer Research : CR·Zhi-Wei ChangYan-Ru Qin
Aug 26, 2017·Cellular and Molecular Life Sciences : CMLS·Soichiro YamamuraRajvir Dahiya
Nov 18, 2017·International Journal of Genomics·Marco RagusaMichele Purrello
May 3, 2019·Molecular Genetics & Genomic Medicine·Guozheng LiuFengyong Wang
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mi-Die XuXiang Du
Jan 4, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-Fard, Mohammad Taheri
Jan 29, 2021·BioMed Research International·Weihong SunHaiping Song
Apr 15, 2020·Biochemical and Biophysical Research Communications·Tomomi FujiiChiho Ohbayashi
Jul 27, 2021·Cancer Management and Research·Bo-Hao ZhengXiao-Jian Ni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.