Reciprocal temporospatial patterns of Msx2 and Osteocalcin gene expression during murine odontogenesis

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
M BidderD A Towler

Abstract

Msx2 is a homeodomain transcription factor that regulates craniofacial development in vivo and osteocalcin (Osc) promoter activity in vitro. Msx2 is expressed in many craniofacial structures prior to embryonic day (E) E14 but is expressed at later stages in a restricted pattern, primarily in developing teeth and the calvarium. We examine Osc expression by in situ hybridization during murine development, detailing temporospatial relationships with Msx2 expression during preappositional and appositional odontogenesis and calvarial osteogenesis. Osc expression at E14-14.5 is very low, limited to a few perichondrial osteoblasts in the dorsal aspect of developing ribs. At E16.5 and E18.5, Osc expression is much higher, widely expressed in skeletal osteoblasts, including calvarial osteoblasts that do not express Msx2. No Osc is detected in early preappositional teeth that express Msx2. In incisors studied at an early appositional phase, Msx2 is widely expressed in the tooth, primarily in ovoid preodontoblasts and subjacent dental papilla cells. Osc is detected only in a small number of maturing odontoblasts that also express alpha1(I) collagen (Colla1) and that are postproliferative (do not express histone H4). Msx2 expression greatl...Continue Reading

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Citations

Oct 20, 2006·Reviews in Endocrine & Metabolic Disorders·Jane B LianDaniel W Young
May 20, 2008·The Journal of Biological Chemistry·Su-Li ChengDwight A Towler
Apr 18, 2012·Photomedicine and Laser Surgery·Yoshiko Murakami MasudaYuichi Kimura
Apr 8, 2004·Journal of Periodontology·Emi ShimizuYorimasa Ogata
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May 18, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·M BidderM I Boyer
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Mar 3, 2009·BMB Reports·Young-Mi ChaeJe-Yoel Cho
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