PMID: 9193149Jan 1, 1997Paper

Reciprocal trophic interactions between climbing fibres and Purkinje cells in the rat cerebellum

Progress in Brain Research
P StrataF Rossi

Abstract

In the adult cerebellum both the climbing fibre arbour and the Purkinje cell are very plastic and each element is able to exert a remarkable action on the other one. The adult phenotype of the Purkinje cell is strictly dependent on the presence of its climbing fibre arbour. When the climbing fibre is missing, the Purkinje cell undergoes a hyperspiny transformation and becomes hyperinnervated by the parallel fibres. However, this change is fully reversible. The climbing fibre-deprived Purkinje cell is able to elicit sprouting of nearby located intact climbing fibres and the new arbour is able to fully restore synaptic connections which appear normal both morphologically and functionally. Multiple climbing fibre innervation of a single Purkinje cell persists in the adult hypogranular cerebellum. The different fibres are distributed to separate dendritic regions, suggesting a local competition between the different arbours for their territory. It is postulated that in the intact rat, an activity dependent mechanism of the parallel fibre favours the predominance of one arbour with the elimination of its competitors. When the Purkinje cell is deleted, the climbing fibre arbour becomes heavily atrophic and reduced in size. The analys...Continue Reading

Citations

Oct 14, 2010·The Cerebellum·Jakob JankowskiStephan Baader
Jun 28, 2019·The Journal of Comparative Neurology·Violetta InsoliaMaria G Bottone
May 18, 2007·Developmental Neurobiology·Yoshiko TakagishiYoshiharu Murata
Dec 6, 2003·The European Journal of Neuroscience·Izumi SugiharaRachel M Sherrard
Sep 1, 2016·Nature Communications·Vincent Breton-ProvencherArmen Saghatelyan
Jun 11, 2020·Revista da Associação Médica Brasileira·Andrei Fernandes Joaquim
Jan 27, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Yueh-Chi WuSheng-Han Kuo
Apr 1, 2010·Experimental Neurology·M T ViscomiM Molinari
May 6, 2003·Developmental Biology·Yan ZhuSarah Guthrie
Dec 31, 2003·Neuroscience·M T ViscomiM Molinari

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