PMID: 8966210Nov 1, 1995Paper

Reciprocal trophic interactions in the adult climbing fibre-Purkinje cell system

Progress in Neurobiology
F Rossi, Piergiorgio Strata

Abstract

This article reviews a series of experiments aimed at investigating the reciprocal trophic interactions which regulate the normal morphofunctional features and the plasticity of the adult rodent climbing fibre-Purkinje cell system. Climbing fibre deprivation induces profound functional and structural changes in the Purkinje cell. Among others, proximal Purkinje cells dendrites become studded with numerous newly formed spines some of which are innervated by parallel fibres. These structural modifications are reversed if the Purkinje cell is reinnervated by another climbing fibre. These results indicate that the olivocerebellar input inhibits spinogenesis on proximal Purkinje cell dendrites and prevents other afferents from invading its own target domain. It is proposed that the normal distribution of synapses on the Purkinje cell dendritic tree is controlled by the interplay between climbing and parallel fibre influences on Purkinje cell dendrites. Following Purkinje cell death, the distal climbing fibre branches are withdrawn. This atrophy progresses according to the time and mode of Purkinje cell degeneration and it is reversed if the climbing fibre is provided with a new target Purkinje cell. In addition, sprouting from intac...Continue Reading

References

Jan 1, 1992·Trends in Neurosciences·J W Fawcett
May 1, 1992·Biochemical Society Transactions·R Hawkes
Jul 1, 1992·Journal of Neurobiology·D H BairdC A Mason
Jul 1, 1991·The Journal of Cell Biology·V WitzemannB Sakmann
Aug 1, 1991·Trends in Neurosciences·A Björklund
Aug 1, 1991·Trends in Neurosciences·C Sotelo, R M Alvarado-Mallart
Apr 8, 1990·The Journal of Comparative Neurology·M WassefR Hawkes
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G Campbell, D O Frost
Jan 1, 1989·Annual Review of Neuroscience·J H Skene
Jun 15, 1987·The Journal of Comparative Neurology·B GhettiL C Triarhou
Mar 1, 1972·The Journal of Physiology·T Lomo, J Rosenthal
Dec 1, 1974·The Journal of Cell Biology·S L PalayV Chan-Palay
Sep 1, 1972·The Journal of Comparative Neurology·S E Kornguth, G Scott
Jan 1, 1973·Zeitschrift Für Anatomie Und Entwicklungsgeschichte·V Chan-Palay
Nov 1, 1970·The Journal of Comparative Neurology·R F Schild
Jun 1, 1969·Brain Research·G Raisman
Sep 1, 1966·The Journal of Comparative Neurology·F Moatamed
Jan 1, 1981·Annual Review of Neuroscience·N Tsukahara
Jan 1, 1982·Annual Review of Psychology·C W Cotman, M Nieto-Sampedro
Oct 1, 1984·Photochemistry and Photobiology·T Ito, A Ito
Jan 1, 1981·Experimental Brain Research·P G MontaroloP Strata
May 1, 1984·Experimental Neurology·R E KingsleyR H Seall
Jan 1, 1981·Annual Review of Neuroscience·M C BrownW G Hopkins

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Citations

Sep 15, 1998·Trends in Neurosciences·P Strata, F Rossi
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M FernandezI Torres-Aleman
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·M BravinP Strata

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