PMID: 9420879Sep 1, 1995Paper

Reciprocal variations in insulin-stimulated glucose uptake and pancreatic insulin secretion in women with normal glucose tolerance

Journal of the Society for Gynecologic Investigation
M P DiamondR A DeFronzo

Abstract

Maintenance of normal glucose tolerance is achieved in subjects with a wide range of insulin sensitivity. It follows, therefore, that the body must possess a sensor mechanism that assesses the body's sensitivity to insulin and appropriately adjusts the secretion of insulin to maintain normal glucose homeostasis. We evaluated the relation between insulin action and insulin secretion. Euglycemic hyperinsulinemic clamp (1 mU/kg.minute) and hyperglycemic clamp (+125 mg/dL) studies were performed in 32 non-obese women with normal oral glucose tolerance tests. The subjects were stratified into quartiles based upon their insulin-mediated rate of glucose uptake during the euglycemic insulin clamp. Total body glucose disposal varied threefold, ranging from 4.00 to 11.18 mg/kg.minute. A significant inverse relation (r = -0.50, P < .01) was noted between the rate of total body insulin-mediated glucose disposal (insulin clamp) and the total plasma insulin response during the hyperglycemic clamp. Women in the lowest quartile of insulin sensitivity (mean glucose uptake 5.07 +/- 0.20 mg/kg.minute) had the highest plasma insulin response during the hyperglycemic clamp (109 +/- 20 microU/mL). In contrast, women in the highest quartile of insuli...Continue Reading

Citations

Jun 10, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Mandeep Bajaj, Ralph A Defronzo
Nov 11, 2011·Science Translational Medicine·Kirstin F BarnhartRenata Pasqualini
May 16, 2006·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·George B KudoloJanet Blodgett
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
Aug 10, 2011·The American Journal of Cardiology·Ralph A DeFronzo, Muhammad Abdul-Ghani
Aug 2, 2013·Diabetes Care·Ralph A DeFronzoMuhammad Abdul-Ghani
Nov 19, 2005·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·George B KudoloJanet Blodgett
Nov 12, 2015·PloS One·Andrea De GaetanoSimona Panunzi

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