Reclassification and subtyping of so-called malignant fibrous histiocytoma of bone: comparison with cytogenetic features.

Clinical Sarcoma Research
Fredrik MertensMaria Debiec-Rychter

Abstract

The diagnostic entity malignant fibrous histiocytoma (MFH) of bone is, like its soft tissue counterpart, likely to be a misnomer, encompassing a variety of poorly differentiated sarcomas. When reviewing a series of 57 so-called MFH of bone within the framework of the EuroBoNeT consortium according to up-to-date criteria and ancillary immunohistochemistry, a fourth of all tumors were reclassified and subtyped. In the present study, the cytogenetic data on 11 of these tumors (three myoepithelioma-like sarcomas, two leiomyosarcomas, one undifferentiated pleomorphic sarcoma with incomplete myogenic differentiation, two undifferentiated pleomorphic sarcomas, one osteosarcoma, one spindle cell sarcoma, and one unclassifiable biphasic sarcoma) are presented. All tumors were high-grade lesions and showed very complex karyotypes. Neither the overall pattern (ploidy level, degree of complexity) nor specific cytogenetic features distinguished any of the subtypes. The subgroup of myoepithelioma-like sarcomas was further investigated with regard to the status of the EWSR1 and FUS loci; however, no rearrangement was found. Nor was any particular aberration that could differentiate any of the subtypes from osteosarcomas detected. chromosome b...Continue Reading

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Citations

Sep 24, 2015·AJR. American Journal of Roentgenology·Gregory Scott StacyAnthony Montag
Oct 30, 2020·Cancers·Emanuela PalmeriniEric L Staals
Feb 24, 2021·Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews·Mark M CullenWilliam C Eward

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