Recognising the signals for endosomal trafficking

Current Opinion in Cell Biology
Saroja WeeratungaBrett M Collins

Abstract

The endosomal compartment is a major sorting station controlling the balance between endocytic recycling and lysosomal degradation, and its homeostasis is emerging as a central factor in various neurodegenerative diseases such as Alzheimer's and Parkinson's. Membrane trafficking is generally coordinated by the recognition of specific signals in transmembrane protein cargos by different transport machineries. A number of different protein trafficking complexes are essential for sequence-specific recognition and retrieval of endosomal cargos, recycling them to other compartments and acting to counter-balance the default endosomal sorting complex required for transport-mediated degradation pathway. In this review, we provide a summary of the key endosomal transport machineries, and the molecular mechanisms by which different cargo sequences are specifically recognised.

References

Mar 17, 2005·Journal of Molecular Biology·Peter KnauthRalf Bohnensack
Jul 30, 2005·The EMBO Journal·Peter van KerkhofGuojun Bu
Sep 6, 2005·Trends in Cell Biology·Jez G Carlton, Peter J Cullen
Feb 8, 2006·Nature Structural & Molecular Biology·Satoshi HiranoSoichi Wakatsuki
Oct 24, 2006·Nature Structural & Molecular Biology·Steven L AlamWesley I Sundquist
Apr 24, 2007·Nature Reviews. Molecular Cell Biology·Roger L Williams, Sylvie Urbé
Aug 22, 2009·Nature Reviews. Molecular Cell Biology·Linton M Traub
Nov 17, 2009·Seminars in Cell & Developmental Biology·Jan R T van WeeringPeter J Cullen
Feb 13, 2010·The EMBO Journal·Xuefeng Ren, James H Hurley
Aug 25, 2010·The Journal of Cell Biology·Benjamin E L LaufferMark von Zastrow
Sep 30, 2010·Traffic·Suzanne J NorwoodBrett M Collins
Mar 31, 2011·Nature Reviews. Molecular Cell Biology·Caroline GrabbeIvan Dikic
Apr 23, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rajesh GhaiBrett M Collins
Jul 19, 2011·Developmental Cell·William M HenneScott D Emr
Sep 1, 2011·The EMBO Journal·Jatta Huotari, Ari Helenius
Dec 24, 2011·Structure·Katarina MoravcevicMark A Lemmon
Dec 24, 2011·Nature Cell Biology·Peter J Cullen, Hendrik C Korswagen
Mar 13, 2012·Structure·Monica AgromayorRoger L Williams
Apr 12, 2012·The Journal of Cell Biology·Florian SteinbergPeter J Cullen
May 9, 2012·Nature Cell Biology·Ralph Thomas BöttcherReinhard Fässler
Sep 15, 2012·Developmental Cell·Michael J ClagueSylvie Urbé
Nov 14, 2012·Journal of Cell Science·Matthew N J Seaman
Feb 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Rajesh GhaiBrett M Collins
Nov 5, 2013·Cold Spring Harbor Perspectives in Biology·Linton M Traub, Juan S Bonifacino
Jan 25, 2014·Nature Communications·Li Shen LooWanjin Hong
Apr 9, 2014·Seminars in Cell & Developmental Biology·Cameron C ScottJean Gruenberg
Apr 15, 2014·Seminars in Cell & Developmental Biology·Elizabeth GrangerPhilip Woodman
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Matthew GallonPeter J Cullen
Jan 14, 2016·Nature·Katharina KetelVolker Haucke
Feb 26, 2016·Molecular Biology of the Cell·Audrey S M ChanNathan J Pavlos

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Citations

Jul 8, 2020·Journal of Neuroscience Research·Vania Macías-CalvioMaría-Paz Marzolo
Jan 30, 2021·PLoS Genetics·Brian T EmmerDavid Ginsburg
Dec 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maša MavriValentina Kubale
Oct 21, 2020·Current Opinion in Cell Biology·Frances M Brodsky, Jennifer L Stow
Mar 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yan ZhangFei Sun
Mar 4, 2021·International Journal of Molecular Sciences·Bibhas AmatyaPedro A Jose
Mar 16, 2021·Frontiers in Cell and Developmental Biology·Tiffany G RoachDaniel G S Capelluto
Dec 17, 2020·American Journal of Physiology. Cell Physiology·Fiona J McDonald
Apr 2, 2021·The EMBO Journal·Nicholas D Serra, Meera V Sundaram
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ludger Johannes
Sep 1, 2021·Proceedings of the National Academy of Sciences of the United States of America·Xin YongDa Jia

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