Recognition and stabilization of peptide alpha-helices using templatable nanoparticle receptors

Journal of the American Chemical Society
Ayush VermaVincent M Rotello

Abstract

alpha-Helices are important structural elements in proteins. To provide a scaffold for the facial recognition of peptides, we have explored the interaction of cationic mixed monolayer protected clusters (MMPCs) with a tetra-aspartate peptide in water. In these studies, substantial enhancement of peptide helicity was observed upon addition of the MMPC. Significantly, this stabilization increased with time, demonstrating templation of the monolayer to the peptide helix.

Citations

Sep 11, 2010·Journal of the American Chemical Society·Yu HoshinoKenneth J Shea
Jun 12, 2012·Journal of the American Chemical Society·Albert RimolaPiero Ugliengo
May 31, 2006·Chemical Communications : Chem Comm·Joseph W E WorrallVincent M Rotello
Jul 5, 2007·Chemical Communications : Chem Comm·Partha S GhoshVincent M Rotello
Mar 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marie-Eve Aubin-TamKimberly Hamad-Schifferli
Oct 18, 2005·Current Opinion in Chemical Biology·Chang-Cheng YouVincent M Rotello
Dec 22, 2009·Chemical Communications : Chem Comm·Young-Pil KimJianghong Rao
Nov 2, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Partha S GhoshVincent M Rotello
Jan 15, 2009·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Cyrille Gautier, Thomas Bürgi
Jul 3, 2010·Chemical Society Reviews·Daniel Aili, Molly M Stevens
Jul 31, 2010·Chemical Society Reviews·Joseph M Slocik, Rajesh R Naik
Mar 16, 2019·Sensors·Yeşeren SaylanAdil Denizli
Aug 12, 2008·Biomedical Materials·M-E Aubin-Tam, K Hamad-Schifferli
Jun 20, 2019·Chemistry : a European Journal·Yanchao LyuPaolo Scrimin
Oct 5, 2010·Chemical Communications : Chem Comm·Renato BonomiLeonard J Prins
Apr 20, 2017·Sensors·Yeşeren SaylanAdil Denizli
Feb 15, 2006·Soft Matter·Chang-Cheng YouVincent M Rotello
Jun 4, 2011·Small·Xiang LiuFrancesco Stellacci
Jan 22, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Zuzana GaraiovaMaria Bryszewska
Jan 17, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Mahantappa HalimaniSouvik Maiti
Apr 14, 2005·Chemical Reviews·J Christopher LoveGeorge M Whitesides
Feb 26, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Logan M WilderRichard M Crooks
Aug 18, 2005·Journal of the American Chemical Society·Satoshi YamaguchiItaru Hamachi
May 5, 2005·Journal of the American Chemical Society·P K SudeepK George Thomas

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