PMID: 2107545Mar 1, 1990Paper

Recognition by CD8 on cytotoxic T lymphocytes is ablated by several substitutions in the class I alpha 3 domain: CD8 and the T-cell receptor recognize the same class I molecule

Proceedings of the National Academy of Sciences of the United States of America
J M ConnollyT A Potter

Abstract

The CD8 molecule on class I-reactive cytotoxic T lymphocytes (CTLs) is believed to function as a coreceptor along with the alpha beta T-cell receptor. Whereas the alpha beta T-cell receptor recognizes polymorphic residues in the alpha 1/alpha 2 domains of the class I molecule, the CD8 molecule is believed to recognize monomorphic class I residues. Our previous experiments suggested that residue 227 in the alpha 3 domain of major histocompatibility complex class I molecules contributes to the determinant recognized by CD8. By using a panel of site-directed mutants of H-2Dd, this observation has been extended herein. Our findings indicate that for recognition by CD8-dependent CTLs, residue 227 must be either glutamic acid or aspartic acid and cannot be either basic or uncharged. However, the recognition by CD8-independent CTLs is unaffected by any of the substitutions at position 227 of H-2Dd. Similarly, alterations of other charged residues at positions 222, 223, and 229 have an analogous effect to substitution at residue 227, whereas substitutions at residues 192 and 232 do not affect the reactivity of CD8-dependent or CD8-independent CTLs. In addition, mutant H-2Dd molecules that are not recognized by CD8-dependent CTLs are un...Continue Reading

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E NakayamaL J Old
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C E RuddS F Schlossman
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A KupferS L Swain
Apr 2, 1987·Nature·Z DembićH von Boehmer
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F EmmrichK Eichmann
Nov 3, 1988·Nature·A M NormentD R Littman
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K OzatoJ G Seidman
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·C S ReissS J Burakoff

❮ Previous
Next ❯

Citations

May 20, 1991·Journal of Molecular Biology·M A SaperD C Wiley
Jan 1, 1994·Molecular Aspects of Medicine·A MorrisS Young
Apr 1, 1993·Immunology Today·A M O'Rourke, M F Mescher
Jun 1, 1991·Current Opinion in Immunology·R M Steinman, J W Young
Jan 1, 1993·Transplant Immunology·P F HalloranJ Madrenas
Jun 7, 2005·Human Immunology·Wendy T N SwelsenElla M van den Berg-Loonen
Jan 16, 2002·Current Opinion in Immunology·Rolf König
Nov 26, 2002·Tissue Antigens·W T N SwelsenE M van den Berg-Loonen
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lijin LiWilliam E Gillanders
Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·P W HedrickP Parham
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M C MiceliJ R Parnes
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·U A BetzJ Klein
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·P A GiblinP B Kavathas
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·W M Yokoyama
Oct 1, 1992·The Journal of Experimental Medicine·J Zemmour, P Parham
Sep 1, 1994·The Journal of Experimental Medicine·W P Fung-LeungC Y Lau
May 1, 1996·The Journal of Experimental Medicine·Y QiU D Staerz
Dec 1, 1996·The Journal of Experimental Medicine·V RenardI F Luescher
Aug 14, 2013·The Journal of Experimental Medicine·John A H HoerterNicholas R J Gascoigne
Nov 6, 2007·International Immunology·Igor M BelyakovJay A Berzofsky
Oct 23, 1997·Tissue Antigens·E Martinez-NavesP Parham
Oct 19, 2001·Proceedings of the National Academy of Sciences of the United States of America·T A PotterA Kupfer
Oct 1, 1990·Current Opinion in Cell Biology·A M O'Rourke, M F Mescher

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.