Recognition molecules myelin-associated glycoprotein and tenascin-C inhibit integrin-mediated adhesion of neural cells to collagen

Journal of Neuroscience Research
M BachmannM Schachner

Abstract

Because of the importance of collagens in mediating cell-substrate interactions and the association of collagens with neural recognition molecules in the peripheral nervous system, the ability of neural recognition molecules to modify the substrate properties of collagens, in particular collagen type I, for cell adhesion was determined. Two cell lines, the N2A neuroblastoma and PC12 pheochromocytoma, were investigated for their capacity to adhere to different collagen types in the absence or presence of several neural recognition molecules. Adhesion of N2A or PC12 cells and membrane vesicles from PC12 cells to collagen type I was reduced when the collagen had been preincubated prior to its application as substrate with the extracellular domain of myelin-associated glycoprotein (s-MAG) or, as control, fibroblast tenascin-C (F-tenascin). In mixture with other collagen types, s-MAG was only able to reduce the adhesiveness of collagen types III and V, but not of collagen types II and IV. F-tenascin reduced the adhesiveness of all collagen types tested. In contrast to F-tenascin, s-MAG had to be present during fibrillogenesis to exert its effect, indicating that it must be coassembled into the collagen fibril to block the binding si...Continue Reading

References

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Citations

Apr 29, 1999·Journal of Neuroscience Research·H YangM Schachner
Jun 15, 1995·Journal of Neuroscience Research·A Meyer-FrankeM Schachner
May 20, 1998·Molecular Neurobiology·K C BreenF D Hayes
Dec 13, 2001·Neurochemistry International·Galina A UshakovaGalina G Skibo
Apr 25, 2006·Journal of Neurotrauma·Nicole Klapka, Hans Werner Müller
Jan 30, 2003·Glia·Nicolas HeckAndreas Faissner
Jan 24, 2007·Journal of Neurochemistry·Richard H Quarles
Jan 27, 2007·Journal of Neurochemistry·Gabriele Loers, Melitta Schachner
Nov 13, 2001·The Journal of Biological Chemistry·Gloria A Di LulloJames D San Antonio
Feb 16, 2018·Biological Reviews of the Cambridge Philosophical Society·Bart NieuwenhuisJames W Fawcett

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