PMID: 7028157Jun 1, 1981Paper

Recognition of base sequences by regulatory proteins in procaryotes and eucaryotes

Bioscience Reports
C Hélène

Abstract

A model is described whereby (i) regulatory proteins recognize one face of the DNA double helix on non-adjacent DNA regions brought close together in space through folding around nucleosomes, (ii) regulatory sequences may occur inside gene structures, and (iii) the recognition of regulatory sequences might be modulated by short (4-6 base-pairs) insertions or deletions in introns or upstream from the transcription start site. This model might apply not only to eucaryotes but also to procaryotic organisms whose DNA is organized through interactions with histone-like proteins. Consequences of the model regarding the binding of regulatory proteins in procaryotes are suggested.

References

Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·J H Wilson
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Dec 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·D Lohr, K E Van Holde
Jun 26, 1979·Biochemistry·K Tatchell, K E Van Holde
Dec 11, 1979·Nucleic Acids Research·A KressmannM L Birnstiel
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Oct 24, 1980·Nucleic Acids Research·H Weintraub

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Citations

Jun 14, 2013·Nucleic Acids Research·Elisa DuránModesto Orozco
Jan 1, 1982·Progress in Biophysics and Molecular Biology·C Hélène, G Lancelot
Jul 25, 2012·Biophysical Journal·Alberto PérezModesto Orozco

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