PMID: 9185208May 1, 1997Paper

Recognition of central nervous system metastases in children with metastatic primary extracranial neuroblastoma

Pediatric Hematology and Oncology
J BlattJ Mirro

Abstract

In children with primary extracranial neuroblastoma (NB), intrinsic central nervous system (CNS) metastases (brain parenchyma or leptomeninges) are thought to occur rarely. This study was done to evaluate our anecdotal experience, which suggested that CNS involvement is becoming more frequent. Reports of computed tomographic (CT) and magnetic resonance (MR) imaging scans, biopsies, cerebrospinal fluid (CSF) cytologies, and autopsies were reviewed for children with stage IV NB diagnosed in 1978-1993 and followed at the Children's Hospital of Pittsburgh. Of 43 children over the age of 1 year, CNS metastases were documented in 7 (16.2%). Six patients developed signs or symptoms best explained by the presence of CNS tumor and had radiographic and/or histologic evidence of parenchymal disease (cortical masses on CT and MR, n = 3; suprasellar mass on CT, n = 1; diffuse leptomeningeal carcinomatosis by MR and/or autopsy, n = 2). CSF cytologies were positive in the one patient so tested. An additional asymptomatic patient had extensive CNS involvement at autopsy. In two of these children, the CNS was the first or only site of recurrent disease. It is concluded that intrinsic CNS disease is not uncommon in children with NB over the age ...Continue Reading

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Citations

Jan 9, 2009·Pediatric Surgery International·Madhavi ChawlaRakesh Kumar
Apr 17, 2002·Pediatric Neurology·Richard G CurlessSteven Falcone
Jun 11, 1999·Journal of Pediatric Hematology/oncology·S G DuBoisK K Matthay
Sep 1, 2012·Case Reports in Neurological Medicine·Nathan C RowlandHoward M Katzenstein
Apr 23, 2010·AJR. American Journal of Roentgenology·Nicholas D'AmbrosioSasan Karimi
Dec 25, 2013·Academic Radiology·Seyed Ali NabavizadehArastoo Vossough
Mar 9, 2010·International Journal of Radiation Oncology, Biology, Physics·Victoria J CroogSuzanne L Wolden
Mar 29, 2002·Medical and Pediatric Oncology·Catharina DhoogeBart Vanzieleghem
Nov 5, 2003·Medical and Pediatric Oncology·Tang-Her JaingChuen Hsueh
Mar 17, 2005·Pediatric Blood & Cancer·Hyoung Soo ChoiHyo Seop Ahn
Jul 2, 2020·Pediatric Blood & Cancer·Leo Y LuoSuzanne L Wolden
Apr 24, 2014·Journal of Pediatric Hematology/oncology·Ehssan Al-FarajAbha Gupta
Oct 14, 2011·Oncotarget·Alexander A GoldbergVladimir I Titorenko
May 18, 2010·Pediatric Hematology and Oncology·Vasiliki Sidi-FragandreaDimitrios E Koliouskas
Nov 30, 2019·Medical Hypotheses·Vicente Odone-FilhoEduardo Weltman

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