Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients

Journal of Viral Hepatitis
D HuangR Zhu

Abstract

Chronic hepatitis B (CHB) is one of the major public health challenges in the world. Due to a strong interplay between specific T-cell immunity and elimination of hepatitis B virus (HBV), efforts to develop novel immunotherapeutics are gaining attention. TG1050, a novel immunotherapy, has shown efficacy in an animal study. To support the clinical development of TG1050 in China, specific immunity to the fusion antigens of TG1050 was assessed in Chinese patients. One hundred and thirty subjects were divided into three groups as CHB patients, HBV spontaneous resolvers, and CHB patients with HBsAg loss after antiviral treatment. HBV-specific T-cell responses to pools of HBV Core or Polymerase genotype D peptides included in TG1050 were evaluated. HBV Core- or Polymerase-specific cells were detected in peripheral blood mononuclear cells (PBMCs) from the different cohorts. The frequencies and intensities of HBV Core-specific immune responses were significantly lower in CHB patients than in HBsAg loss subjects. In CHB patients, a dominant pool derived from Polymerase (Pol1) was the most immunogenic. CHB patients with low viral loads (<106 IU/mL) were more likely to have a positive response specific to the Core peptide pool. Overall, g...Continue Reading

References

Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Maryline Mancini-BourgineMarie-Louise Michel
Oct 21, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eishiro MizukoshiBarbara Rehermann
Sep 9, 2006·Journal of Immunological Methods·Zoe MoodieSteven G Self
Aug 13, 2008·The Journal of Experimental Medicine·Abhishek DasMala K Maini
Sep 19, 2008·Journal of Virology·Anthony Tanoto TanAntonio Bertoletti
Feb 27, 2010·Journal of Hepatology·Mala K Maini, Anna Schurich
Mar 23, 2012·Journal of Hepatology·UNKNOWN European Association For The Study Of The Liver
Jul 24, 2013·Journal of Gastroenterology and Hepatology·Yan Cui, Jidong Jia
Jan 8, 2014·Molecular Therapy : the Journal of the American Society of Gene Therapy·O GodonUNKNOWN ANRS HB02 study group
Jan 24, 2014·Virologica Sinica·Jia LiuMichael Roggendorf
Dec 17, 2014·Medical Microbiology and Immunology·Marie-Louise MichelStanislas Pol
Jan 13, 2015·Medical Microbiology and Immunology·Eleanor Barnes
Apr 3, 2015·Cold Spring Harbor Perspectives in Medicine·Fabien Zoulim, David Durantel
Jul 3, 2015·Cold Spring Harbor Perspectives in Medicine·Anthony TanAntonio Bertoletti
Nov 14, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Norah A TerraultUNKNOWN American Association for the Study of Liver Diseases
Dec 20, 2015·Gastroenterology·Jang-June ParkUNKNOWN HBRN
Apr 17, 2016·Journal of Hepatology·Antonio Bertoletti, Carlo Ferrari

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