Recognition of filigree pattern expands the concept of micropapillary subtype in patients with surgically resected lung adenocarcinoma.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Erjia ZhuChang Chen

Abstract

Our study aimed to validate the clinicopathological characteristics and prognosis of lung adenocarcinoma (ADC) with a filigree pattern and to further investigate the relationship between the filigree pattern and the classical micropapillary (MP) pattern. We retrospectively reviewed the clinical and pathologic characteristics of 461 Chinese patients with completely resected ADC (stage I, 310; stage II, 44; stage III, 107). The filigree pattern was more likely to be observed in ADC with a higher stage (p = 0.003) and the classical MP pattern (p < 0.001). Patients with filigree-predominant ADC showed poor survival, similar to those with classical MP-predominant ADC. Multivariate analysis confirmed that the presence of the filigree pattern was an independent prognostic factor for recurrence-free survival (hazard ratio (HR), 2.01; 95% confidence interval (CI), 1.50-2.68; p < 0.001) and overall survival (OS; HR, 1.83; 95% CI, 1.34-2.50; p < 0.001). Patients with both classical MP-positive and filigree-positive ADC had the worst survival compared with those with the filigree pattern or classical MP pattern alone. In stage I, ADC with both the filigree and classical MP patterns had a higher incidence of micrometastasis than ADC with th...Continue Reading

References

Jan 22, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisDavid Yankelewitz
Mar 13, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Akikazu KawaseUNKNOWN Japanese Joint Committee of Lung Cancer Registry
Aug 9, 2013·Journal of the National Cancer Institute·Jun-ichi NitadoriPrasad S Adusumilli
Apr 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ming-Sound TsaoElisabeth M Brambilla
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Apr 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN International Association for the Study of Lung Cancer Staging and Prognostic Factors Committee and Advisory Board Members
Oct 27, 2016·Chest·Frank C DetterbeckLynn T Tanoue
Apr 9, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Chenyang DaiChang Chen
Jul 29, 2019·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsura EmotoPrasad S Adusumilli
Jul 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erik Thunnissen, Douglas Flieder
Jul 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Katsura EmotoWilliam D Travis

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