PMID: 6166874Aug 13, 1981Paper

Recognition of H-2 domains by cytotoxic T lymphocytes

Nature
C WeyandJ Goronzy

Abstract

The polymorphic major histocompatibility antigens (H-2) have a crucial role in the activation of antigen-specific T lymphocytes. Thus, H-2 antigens are not only recognized by allogenic lymphocytes leading to generation of cytotoxic T lymphocytes (CTLs), but it has also been demonstrated that in syngeneic systems most T cells are only able to recognize foreign antigens in conjunction with their own MHC (major histocompatibility complex) antigens. This phenomenon, termed H-2 restriction, may be the key to our understanding to the biological function of MHC antigens. It is not clear whether recognition by T cells of H-2 on a molecular level is confined to particular domains on the H-2 molecule, nor whether the same polymorphic H-2 sites, which are characterized by antibodies, are recognized by allogeneic as well as by H-2 restricted syngeneic CTLs. Previous findings indicate the existence of at least two major polymorphic domains on the H-2Kk molecule as defined by antibodies. Here we show the existence of CTLs with specifity for these polymorphic domains, and the preferential recognition of a particular domain by both alloreactive as well as H-2 restricted CTLs.

References

Jul 1, 1979·European Journal of Immunology·K F Lindahl, H Lemke
Jul 1, 1979·The Journal of Experimental Medicine·G J HämmerlingL Flaherty

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Citations

Jan 1, 1984·Immunogenetics·E GoulmyJ J van Rood
Aug 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M McMillanD M Rovner
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·C G MiyadaR B Wallace
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G J HämmerlingU Hämmerling
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J G WoodwardJ A Frelinger
Jan 1, 1983·Springer Seminars in Immunopathology·K EichmannH U Weltzien
Oct 1, 1984·Human Immunology·A W HahnH L Ploegh
Nov 1, 1982·European Journal of Immunology·N KochU Hämmerling
Apr 1, 1989·European Journal of Immunology·G J HämmerlingJ Moreno
Jan 1, 1983·Immunological Reviews·G Berke

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