PMID: 6970321Jan 1, 1980Paper

Recognition of heterologous cells by macrophages. I. Species recognition by mouse and guinea pig macrophages in the phagocytosis of heterologous thymocytes

Microbiology and Immunology
K SanoM Yamada

Abstract

The ability of macrophages to recognize homologous and various heterologous cells was studied in mice, rats, and guinea pigs, in terms of the in vitro phagocytosis of non-opsonized viable thymocytes by macrophages. Mouse, rat, and guinea pig macrophages were found to phagocytize actively thymocytes from certain heterologous animals, including chickens. For instance, mouse macrophages displayed conspicuous phagocytic activities against chicken and duck thymocytes, moderate activities against guinea pig and frog thymocytes and weak activities against rat and mouse thymocytes. On the other hand, guinea pig macrophages revealed a different behaviour: they ingested only chicken thymocytes. These observations strongly suggested that mammalian macrophages possess some ability to discriminate homologous from certain heterologous thymocytes. The results, however, did not necessarily support the idea that the degree of phagocytosis is simply related to the phylogenetic distance between the animal species from which thymocytes and macrophages originated, because of the apparent exception in the mode of phagocytosis by guinea pig macrophages. Evidence demonstrating that antibodies are not involved in this phenomenon will be presented in th...Continue Reading

References

Jun 1, 1975·Journal of Immunological Methods·W F Davidson, C R Parish
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·U GaliliE Klein
Jan 1, 1977·Annual Review of Biochemistry·S C SilversteinZ A Cohn
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M Kay
Jun 1, 1974·The Journal of Allergy and Clinical Immunology·L R LopezD W Talmage
Sep 1, 1970·The Journal of Allergy·I Siegel

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