PMID: 6970322Jan 1, 1980Paper

Recognition of heterologous cells by macrophages. II. The mechanism of phagocytosis of chicken thymocytes by mouse and guinea pig macrophages

Microbiology and Immunology
M SugimotoY Egashira

Abstract

Mouse and guinea pig macrophages cultured in vitro actively phagocytize non-opsonized thymocytes from certain heterologous animals including chickens, as shown in the accompanying paper (11). The present study was undertaken to investigate the mechanism of this phenomenon, using the phagocytosis of chicken thymocytes (c-thymocytes) by mouse and guinea pig macrophages. The involvement in this phenomenon of natural IgG passively adsorbed in situ to macrophages was excluded, since the phagocytosis of c-thymocytes was not significantly affected by the treatment of macrophages with homologous IgG or rabbit anti-sera directed toward homologous IgG. The involvement of lectin- or sugar-like receptors seems also to be unlikely, since various glycoproteins showed no significant effect. c-Thymocytes treated with normal mouse serum (NMS) but not with heat-inactivated NMS were strongly stained with goat anti-mouse C3 by an indirect immunofluorescent technique, and became extremely vulnerable to adherence to and phagocytosis by mouse macrophages, suggesting that c-thymocytes are an activator of the alternative pathway of mouse complement. These results as a whole raise the possibility that mouse and guinea pig macrophages can phagocytize c-t...Continue Reading

References

Jan 1, 1977·Annual Review of Biochemistry·S C SilversteinZ A Cohn
Oct 1, 1977·Carbohydrate Research·T KondoT Osawa
Nov 29, 1978·Biochemical and Biophysical Research Communications·H Kolb, V Kolb-Bachofen
Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·M M Kay

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