PMID: 9419448Jan 7, 1998Paper

Recognition of melanoma-derived antigens by CTL: possible mechanisms involved in down-regulating anti-tumor T-cell reactivity

Critical Reviews in Immunology
L RivoltiniG Parmiani

Abstract

Several T cell-recognized epitopes presented by melanoma cells have been identified recently. Despite the large array of epitopes potentially available for clinical use, it is still unclear which of these antigens could be effective in mediating anti-tumor responses when used as a vaccine. Preliminary studies showed that immunization of melanoma patients with epitopes derived from proteins of the MAGE family may result in significant clinical regressions. However, no sign of systemic immunization could be observed in peripheral blood of treated patients. Conversely, significant immunization (detected as increased antigen-specific CTL activity in peripheral blood) was obtained by vaccinating HLA-A2.1+ melanoma patients with the immunodominant epitope (residues 27-35) of the differentiation antigen MART-1, but this immunization was not accompanied by a significant clinical response. To implement immunotherapeuties capable of significantly impacting disease outcome, it is necessary to identify the potential mechanisms responsible for the failure of some antigens to mediate significant anti-tumor responses in vivo. In the case of the MART-1(27-35) epitope, we hypothesize that one of these mechanisms may be related to the existence ...Continue Reading

Citations

Aug 24, 1999·Medical Oncology·P JantscheffC Rochlitz
Apr 27, 2000·Critical Reviews in Oncology/hematology·A J Bremers, G Parmiani
Jul 20, 1999·Dermatologic Clinics·A R Hudson, B R Smoller
Oct 28, 2005·Expert Review of Anticancer Therapy·Roy NoyYoram Reiter
Feb 1, 2000·Journal of Cellular Physiology·C CastelliG Parmiani
Dec 17, 2008·Journal of Perinatology : Official Journal of the California Perinatal Association·S Velaphi, A Van Kwawegen
Jan 11, 2000·International Journal of Cancer. Journal International Du Cancer·R SomasundaramD Herlyn
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Galit DenkbergYoram Reiter
Jun 11, 1999·International Journal of Cancer. Journal International Du Cancer·E JägerM J Maeurer
Nov 26, 2002·Immunological Reviews·Licia RivoltiniGiorgio Parmiani

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