Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant

PloS One
Barbara BottazziAlberto Mantovani

Abstract

Long pentraxin 3 (PTX3) is a non-redundant component of the humoral arm of innate immunity. The present study was designed to investigate the interaction of PTX3 with Neisseria meningitidis. PTX3 bound acapsular meningococcus, Neisseria-derived outer membrane vesicles (OMV) and 3 selected meningococcal antigens (GNA0667, GNA1030 and GNA2091). PTX3-recognized microbial moieties are conserved structures which fulfil essential microbial functions. Ptx3-deficient mice had a lower antibody response in vaccination protocols with OMV and co-administration of PTX3 increased the antibody response, particularly in Ptx3-deficient mice. Administration of PTX3 reduced the bacterial load in infant rats challenged with Neisseria meningitidis. These results suggest that PTX3 recognizes a set of conserved structures from Neisseria meningitidis and acts as an amplifier/endogenous adjuvant of responses to this bacterium.

References

Jun 26, 1999·Molecular Microbiology·U Vogel, M Frosch
Jul 8, 2000·Microbes and Infection·Y L Tzeng, D S Stephens
Dec 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·M NoursadeghiM B Pepys
Nov 16, 2001·Microbes and Infection·C A Janeway
Mar 7, 2002·Microbes and Infection·Alexander J Szalai
Mar 19, 2003·The Journal of Experimental Medicine·Vega MasignaniMariagrazia Pizza
Mar 21, 2003·European Journal of Immunology·Alma J NautaAnja Roos
Apr 30, 2003·The Journal of Experimental Medicine·Benjamin N GantnerDavid M Underhill
Oct 27, 2004·Antimicrobial Agents and Chemotherapy·Roberta GazianoLuigina Romani
Mar 18, 2005·Annual Review of Immunology·Cecilia GarlandaAlberto Mantovani
Jan 5, 2006·The Journal of Experimental Medicine·Concetta BeninatiGiuseppe Teti
Mar 3, 2006·The Pediatric Infectious Disease Journal·Susan Mathew, Gary D Overturf
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guillermo MadicoSanjay Ram
Jul 11, 2006·Proceedings of the National Academy of Sciences of the United States of America·Marzia M GiulianiMariagrazia Pizza
Aug 30, 2006·Scandinavian Journal of Infectious Diseases·Elene HaralambousMichael Levin
Jan 20, 2007·FEMS Microbiology Reviews·David S Stephens
Mar 29, 2007·The Journal of Experimental Medicine·Sébastien JaillonAlberto Mantovani
Apr 3, 2007·Trends in Microbiology·Muriel C SchneiderChristoph M Tang
Jul 3, 2007·Lancet·David S StephensPetter Brandtzaeg
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Patrick C ReadingAlberto Mantovani
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·F MoscaE De Gregorio
Jul 25, 2008·Shock·Tom SprongMarcel van Deuren
Dec 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Livija DebanSeppo Meri
Mar 17, 2009·The American Journal of Pathology·Danielle G SouzaMauro M Teixeira
Jul 28, 2009·The Journal of Biological Chemistry·Ying Jie MaPeter Garred
Sep 8, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carmen D'AngeloLuigina Romani
Dec 9, 2009·Annual Review of Immunology·Barbara BottazziAlberto Mantovani

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Citations

Dec 10, 2015·Current Opinion in Immunology·Cecilia GarlandaAlberto Mantovani
Oct 21, 2015·Trends in Microbiology·Suan-Sin FooSuresh Mahalingam
Mar 30, 2016·Seminars in Immunology·Sébastien JaillonAlberto Mantovani
Feb 28, 2016·Journal of Hepatology·Barbara BottazziAlberto Mantovani
Dec 6, 2017·Frontiers in Immunology·Mariëlle C HaksTom H M Ottenhoff
Feb 8, 2018·Physiological Reviews·Cecilia GarlandaAlberto Mantovani
Jan 7, 2020·Current Opinion in Pediatrics·Etsuro NanishiOfer Levy
Oct 27, 2016·Immunological Reviews·Kenji DaigoAlberto Mantovani
Oct 26, 2016·Cellular Microbiology·Rishi D Pathirana, Maria Kaparakis-Liaskos
Dec 12, 2018·PLoS Pathogens·Valeria CiancarellaMaria Lina Bernardini
Mar 12, 2020·Mycobiology·Yuening KangLiangjing Lu
Jan 23, 2021·Cell Death and Differentiation·Guido ForniUNKNOWN COVID-19 Commission of Accademia Nazionale dei Lincei, Rome
Jan 15, 2017·Microbiology Spectrum·Sébastien JaillonAlberto Mantovani

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Methods Mentioned

BETA
sedation
ELISA
flow cytometry
FACS

Software Mentioned

GraphPad Prism

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