Recognition of potentially novel human disease-associated pathogens by implementation of systematic 16S rRNA gene sequencing in the diagnostic laboratory.

Journal of Clinical Microbiology
Peter M KellerGuido V Bloemberg

Abstract

Clinical isolates that are difficult to identify by conventional means form a valuable source of novel human pathogens. We report on a 5-year study based on systematic 16S rRNA gene sequence analysis. We found 60 previously unknown 16S rRNA sequences corresponding to potentially novel bacterial taxa. For 30 of 60 isolates, clinical relevance was evaluated; 18 of the 30 isolates analyzed were considered to be associated with human disease.

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Citations

Oct 7, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Silvana K RampiniErik C Böttger
Mar 2, 2012·Emerging Infectious Diseases·Robert SchlabergMark A Fisher
Jun 29, 2004·Seminars in Cancer Biology·Susan Haupt, Ygal Haupt
Mar 13, 2018·Nucleic Acids Research·Justin WagnerHéctor Corrada Bravo

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