Recognition of pre-processed endogenous antigen by class I but not class II MHC-restricted T cells.

Nature
M T SweetserT J Braciale

Abstract

Class I and class II MHC-restricted T lymphocytes recognize non-native forms of antigen. The presentation of antigen to these two classes of T lymphocytes can occur through distinct pathways. Several mechanisms, including differences in antigen processing in different intracellular compartments, have been proposed to account for these pathway differences. Here we describe a T-cell epitope located on the influenza virus haemaglutinin, which is recognized by both class I and class II MHC-restricted cytolytic T lymphocytes (CTL). When expressed de novo in target cells, from a synthetic minigene encoding only the epitope, this pre-processed antigenic site is recognized by class I but not class II MHC-restricted T lymphocytes, even though target cells treated with the exogenously introduced peptide can be recognized by both classes of T cells. Because endogenous expression of the pre-processed antigenic fragment results in differential presentation to class I and class II MHC-restricted CTL, differences between the two different pathways of presentation could lie not at the level of processing but at the level of targeting and/or interaction of processed antigen with MHC.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T J BracialeV L Braciale
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J S Blum, P Cresswell
Jan 1, 1984·Annual Review of Immunology·E R Unanue
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H K Ziegler, E R Unanue

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Citations

Jan 1, 1995·Immunogenetics·H G RammenseeS Stevanoviíc
Feb 1, 1991·Research in Immunology·R L Tarleton
Feb 1, 1991·Current Opinion in Immunology·C V Harding
Feb 1, 1991·Current Opinion in Immunology·N Koch, B Stockinger
Aug 1, 1997·Immunology and Cell Biology·A Suhrbier
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K L RockB Benacerraf
Jan 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·K L RockB Benacerraf
Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P A Roche, P Cresswell
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·A BrooksJ McCluskey
Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C S HahnC M Rice
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·S SandersonN Shastri
Feb 1, 1992·The Journal of Experimental Medicine·L C EisenlohrJ R Bennink
Aug 26, 1999·Current Opinion in Pulmonary Medicine·M AndoH Kohrogi
Apr 1, 1991·Scandinavian Journal of Immunology·C SchmidtI S Misko
Jan 1, 1993·European Journal of Immunology·B StockingerB Hausmann

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