Recognition of the Hyaloperonospora parasitica effector ATR13 triggers resistance against oomycete, bacterial, and viral pathogens

Proceedings of the National Academy of Sciences of the United States of America
Maike C RentelBrian J Staskawicz

Abstract

Phytopathogenic oomycetes cause some of the most devastating diseases affecting agricultural crops. Hyaloperonospora parasitica is a native oomycete pathogen of Arabidopsis and is related to other oomycete phytopathogens that include several species of Phytophthora, including the causal agent of potato late blight. Recently, four oomycete effector genes have been isolated, and several oomycete genomes have been sequenced. We have developed an efficient and genetically amenable system to test putative effector genes using the bacterial pathogen Pseudomonas syringae pv. tomato DC3000. The H. parasitica effector protein ATR13 was delivered via P. syringae by fusing the ATR13 gene with the avrRpm1 type three secretion signal peptide, a bacterial sequence that allows transfer of proteins into the host cell through the bacterial type III secretion system. We also inserted ATR13 into the genome of the turnip mosaic virus, a single-stranded RNA virus. Our results show that delivery of ATR13 via the bacterial or viral pathogen triggers defense responses in plants containing the cognate resistance protein RPP13(Nd), which restricts proliferation of both pathogens. Hence, recognition of ATR13 by RPP13 initiates defense responses that are ...Continue Reading

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Citations

Apr 1, 2010·Briefings in Bioinformatics·Andrés PinzónSilvia Restrepo
Apr 20, 2011·Molecular Plant-microbe Interactions : MPMI·Sarah M CollierPeter Moffett
Dec 1, 2012·Molecular Plant-microbe Interactions : MPMI·Hagop S AtamianIsgouhi Kaloshian
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Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ritu ChaudharyIsgouhi Kaloshian
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Jan 1, 2015·Molecular Plant-microbe Interactions : MPMI·Vivianne G A A Vleeshouwers, Richard P Oliver

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