Recognition of the polypeptide core of mucin by monoclonal antibody MUSE11 against an adenocarcinoma-associated antigen

Japanese Journal of Cancer Research : Gann
Y HinodaA Yachi

Abstract

Monoclonal antibody (MAb) MUSE11 detects an adenocarcinoma-associated antigen and is useful for the serodiagnosis of pancreas cancer. We established a sandwich enzyme immunoassay using MAb MUSE11 and MAb DF3 against a breast cancer-associated mucin core protein as a catcher and a tracer, respectively. With this assay system, the binding of the tracer MAb DF3 to an antigen in the human kidney tissue lysate was clearly inhibited by MAb MUSE11. In addition, MAb MUSE11 showed a significant binding activity to the synthetic peptide corresponding to the tandem repeat of a human epithelial mucin core protein. These data suggest that MAb MUSE11 could detect the polypeptide core of a mucin, and may be of use for studying mucin as a gene product.

References

Feb 1, 1986·Gastroenterology·S H Itzkowitz, Y S Kim
Jan 15, 1987·International Journal of Cancer. Journal International Du Cancer·M S LanR S Metzgar
Oct 15, 1989·International Journal of Cancer. Journal International Du Cancer·J BurchellT Duhig
Jan 1, 1989·Cell Calcium·R D Burgoyne, M J Geisow
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SiddiquiD Kufe
Nov 15, 1988·International Journal of Cancer. Journal International Du Cancer·Y HinodaA Yachi
Jan 1, 1983·International Archives of Allergy and Applied Immunology·L LindholmT Lagergård

❮ Previous
Next ❯

Citations

May 1, 1997·Journal of Clinical Pathology·Y AjiokaJ R Jass
Feb 1, 1994·Japanese Journal of Cancer Research : Gann·H HamadaK Hiwada
May 1, 1996·Japanese Journal of Cancer Research : Gann·Y MakiguchiK Imai
May 14, 1998·International Journal of Cancer. Journal International Du Cancer·T SuwaK Imai
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Yuichiro HamanakaYuji Hinoda
Feb 16, 2013·British Journal of Cancer·M RashidD M Swallow
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·K YamashitaY S Kim
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·J BaraR Oriol
Nov 1, 2002·Cornea·James E JumblattMarcia M Jumblatt
Oct 7, 2020·Immunotherapy·Mona PourjafarMassoud Saidijam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.