PMID: 7007816Jan 1, 1980Paper

Recognition of two initiation codons for the synthesis of phage fd gene 2 protein

Molecular & General Genetics : MGG
T F MeyerK Geider

Abstract

Bacteriophage fd gene 2 protein was specifically labeled with radioactive amino acids and was isolated from membranous cell structures as an apparently homogenous protein. Amino acid sequence analysis revealed that the protein was initiated at two distinct AUG codons close to the ribosome binding site. The two resulting translation products were found to begin with a deformylated methionine residue. Initiation at the first signal was used for 90% of the chains and at the second signal for 10% of the sequenced molecules. The use of one or the other chain start may influence functions of gene 2 protein.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J J DunnF W Studier
Jun 1, 1978·European Journal of Biochemistry·K BeyreutherP Dimroth
Dec 1, 1978·Nucleic Acids Research·E BeckM Takanami
Jan 1, 1977·Methods in Enzymology·H Tschesche
Dec 14, 1972·Journal of Molecular Biology·N S Lin, D Pratt
Oct 14, 1968·Journal of Molecular Biology·D Pratt, W S Erdahl
Feb 7, 1980·Nature·D E BüchelB Müller-Hill

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