Recognizing and Grading CAR T-Cell Toxicities: An Advanced Practitioner Perspective

Frontiers in Oncology
Savannah SieversSherry Adkins

Abstract

Over the past decade, chimeric antigen receptor (CAR) T-cell therapy has significantly improved the outlook for many patients with relapsed and/or refractory B-cell malignancies. The use of CAR T-cell therapy and other therapeutic immune effector cells will likely continue to expand with the development of other targets and use in solid tumors. Although these therapies have shown significant promise in the treatment of some malignancies, they can be associated with unique toxicities including cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome which can be fatal if not identified early and treated appropriately. An understanding of how best to manage the toxicities associated with CAR T-cell therapy is continually evolving. Institutions providing CAR T-cell therapy have undergone changes in infrastructure and staffing models in order to safely care for patients receiving this novel therapy. As members of a multi-disciplinary health care team, advanced practice providers play significant roles in caring for this patient population and must be well-versed in the recognition, grading, and appropriate management of CAR T-cell therapy-related toxicities as these providers care for patients in multipl...Continue Reading

References

Aug 30, 2008·Bone Marrow Transplantation·P Ljungman, G Avetisyan
Dec 3, 2013·Lancet·Manuel Ramos-CasalsXavier Bosch
Apr 30, 2014·Cancer Immunology Research·Marcela V MausCarl H June
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Apr 26, 2016·The Journal of Clinical Investigation·Cameron J TurtleDavid G Maloney
Dec 28, 2016·Cell Research·Laura A Johnson, Carl H June
Mar 21, 2017·Clinical Journal of Oncology Nursing·Elizabeth HaltonDonna Miale-Mayer
Jul 18, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cameron J TurtleDavid G Maloney
Sep 20, 2017·Nature Reviews. Clinical Oncology·Sattva S NeelapuElizabeth J Shpall
Dec 12, 2017·The New England Journal of Medicine·Stephen J SchusterCarl H June
Dec 12, 2017·The New England Journal of Medicine·Sattva S NeelapuWilliam Y Go
Feb 1, 2018·The New England Journal of Medicine·Jae H ParkMichel Sadelain
Mar 4, 2018·Journal of Hematology & Oncology·David PorterStephan A Grupp
Mar 23, 2018·Cancer Discovery·Agne TaraseviciuteMichael C Jensen
Jun 2, 2018·The Lancet. Respiratory Medicine·Sawsan RashdanDavid E Gerber
Jun 17, 2018·Journal for Immunotherapy of Cancer·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
Sep 30, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Zahra MahmoudjafariKathryn A Culos
Dec 7, 2018·The New England Journal of Medicine·Stephen J SchusterUNKNOWN JULIET Investigators
Dec 24, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ankit J KansagraShahrukh K Hashmi
Dec 27, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Noelle Frey, David Porter
Dec 29, 2018·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel W LeeSattva S Neelapu
Jan 8, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Helen E Heslop, Elizabeth J Shpall
Jan 25, 2019·American Journal of Respiratory and Critical Care Medicine·Elie AzoulayMichael von Bergwelt-Baildon
Feb 13, 2019·Journal of the National Cancer Institute·Bradley D Hunter, Caron A Jacobson
Mar 21, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Anna Dushenkov, Paiboon Jungsuwadee
Mar 29, 2019·Current Oncology Reports·Paolo Strati, Sattva S Neelapu
Apr 26, 2019·Therapeutic Advances in Hematology·Julio C ChavezMohamed A Kharfan-Dabaja
May 29, 2019·Frontiers in Bioscience (Landmark Edition)·Marta CosciaBenedetto Bruno
Jul 30, 2019·Immunological Reviews·Elad JacobyNirali N Shah
Oct 13, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Julia RuarkMerav Bar
Feb 6, 2020·The New England Journal of Medicine·Enli LiuKatayoun Rezvani
May 1, 2019·Journal of the Advanced Practitioner in Oncology·Sherry Adkins

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Citations

Nov 21, 2020·International Journal of Molecular Sciences·Wen-Ying LinYi-Yen Lee
Nov 7, 2020·Archivum Immunologiae Et Therapiae Experimentalis·Katarzyna SkorkaKrzysztof Giannopoulos
Aug 15, 2021·Current Opinion in Immunology·Ali Can Sahillioglu, Ton N Schumacher
Sep 5, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Dan CohenEinat Even-Sapir

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