Recognizing Atypical Parkinsonisms: "Red Flags" and Therapeutic Approaches

Seminars in Neurology
Nikolaus R McFarland, Christopher W Hess

Abstract

The overlap of signs and symptoms between Parkinson's disease and the atypical parkinsonian syndromes, such as progressive supranuclear palsy, multiple system atrophy, corticobasal syndrome and dementia with Lewy bodies, can render clinical diagnoses challenging. The continued evolution of diagnostic criteria to reflect the increasingly recognized heterogeneous presentations of these diseases further complicates timely recognition and diagnosis. In this review, we provide a diagnostic approach to the classic atypical parkinsonian syndromes, with an emphasis on the key clinical and pathological features of each and the recognition of “red flags” in the setting of recent advances in diagnosis and treatment.

Citations

Jul 30, 2019·Continuum : Lifelong Learning in Neurology·Theresa A Zesiewicz
Dec 14, 2019·Brain : a Journal of Neurology·Matteo BolognaAlfredo Berardelli
Jul 25, 2019·Neurología : publicación oficial de la Sociedad Española de Neurología·A Robles Bayón
Apr 30, 2021·Experimental Brain Research·Steven MorrisonAlex A Grunsfeld
May 23, 2021·Neurobiology of Disease·James E Tomkins, Claudia Manzoni
Jul 28, 2021·Dysphagia·Enrico AlfonsiGiuseppe Cosentino

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