May 1, 1990

Recombinagenicity of caffeine for Candida albicans

Mycopathologia
A Sarachek, L A Henderson

Abstract

Caffeine at concentrations of 0.5 x 10(-2) M or higher inhibited cell replication and induced gene segregations in Candida albicans cultured on defined complete medium. Both responses increased incrementally with increasing caffeine concentrations, and were more severe during incubation at 37 degrees C than 25 degrees C; at 37 degrees C, caffeine levels above 1.5 x 10(-2) M caused cellular inactivation. Caffeine effects occurred only under conditions permitting cell growth, and their magnitudes were greater for unbudded than budding cells, were influenced by cellular genetic backgrounds, and were unaffected by the presence of adenine in the medium. Evaluations of segregations for recessive auxotrophic markers of a four member linkage group carried heterozygously in a cis arrangement in treated cells established that induced segregants arise through either reciprocal or nonreciprocal recombinations. The frequency distributions of classes of reciprocal and nonreciprocal recombinants for these markers conformed with those previously obtained following induction by ultraviolet radiation, indicating that the probabilities of recombinational events within the chromosomal regions defined by the markers are not biased by the difference...Continue Reading

  • References18
  • Citations3

References

  • References18
  • Citations3

Mentioned in this Paper

Antibiotic Resistance, Microbial
Candida albicans
Base Excision Repair
Quick-Pep
Recombination, Genetic
Cell Division Phases
Monospan
Ancobon
Genotoxic Stress
Systemic Candidiasis

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