Recombinant activated factor VII attenuates major arterial bleeding in noncoagulopathic rabbits

European Journal of Anaesthesiology
Marion DurandThomas Lecompte

Abstract

Recombinant activated factor VII (rFVIIa), which is used off-label as an adjuvant therapy for uncontrolled and life-threatening bleeding, might also attenuate intractable bleeding related to macrovascular arterial lesions. Here we evaluated the efficacy of rFVIIa in sealing a large arterial wound in haemostatically competent rabbits. Sixty male New Zealand rabbits were randomly divided into vehicle control and 80 and 200 μg kg⁻¹ rFVIIa groups (n = 20 animals each). A standardized wound of the isolated right carotid artery was made in all rabbits with an 18-G catheter. Bleeding, which was limited by mild compression, was assessed every minute. At 5 min, an intravenous bolus of vehicle or human rFVIIa was given and the animals were further observed for 1 h. Efficacy was assessed from the bleeding duration and blood mass lost. Statistical significance was defined as P less than 0.05. All investigators were blinded to the treatment the animals received. The bleeding duration and blood mass lost were significantly reduced in both rFVIIa dosage groups as compared with the vehicle control group. For the vehicle, 80 and 200 μg kg⁻¹ rFVIIa groups, the median bleeding durations were 56 min (range 7-60 min), 15 min (range 5-60 min) and 10...Continue Reading

References

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Apr 8, 2010·Critical Care : the Official Journal of the Critical Care Forum·Rolf RossaintUNKNOWN Task Force for Advanced Bleeding Care in Trauma

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Citations

Jun 1, 2012·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·M PerlF Gebhard

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