PMID: 15389125Sep 25, 2004Paper

Recombinant activated factor VII in patients with cancer and hemorrhagic disseminated intravascular coagulation

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Sabah SallahNam P Nguyen

Abstract

Hemorrhagic disseminated intravascular coagulation (DIC) associated with the presence of underlying advanced or metastatic tumors are often difficult to control by conventional methods. We report the use of recombinant activated factor VII (rFVIIa) in patients with cancer and bleeding secondary to DIC. A total of 18 patients with cancer met pre-defined criteria for DIC. All patients had failed to respond to transfusion with blood products and treatment of the underlying malignancy prior to the introduction of rFVIIa. The median laboratory data at the time of treatment with rFVIIa were as follows: hemoglobin, 7.7 g/dl; platelets, 54 x 10(9)/l; prothrombin time, 21 s; activated partial thromboplastin time, 41 s fibrinogen, 83 mg/dl; D-dimer, 17 microg/ml; and antithrombin, 32%. The dose of rFVIIa was 90 microg/kg and the median number of doses administered was 5 (range, 3-10). Serial measurements of coagulation parameters were obtained at frequent intervals during treatment with rFVIIa. Of the 18 patients, 15 responded with cessation of bleeding and improvement in coagulation data. The prothrombin time and activated partial thromboplastin time normalized in all responding patients within 24 h of treatment. The median fibrinogen w...Continue Reading

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Citations

Jul 20, 2007·Acta chirurgica Iugoslavica·D VucelićB Spica
Oct 14, 2005·Critical Care : the Official Journal of the Critical Care Forum·R Michael Grounds, Charles Bolan
Mar 30, 2013·Critical Care Clinics·Robert I Parker
Feb 3, 2007·Journal of Thrombosis and Haemostasis : JTH·A M Al Hammadi, S Sallah
Sep 21, 2011·Thrombosis Research·Marcello Di NisioUNKNOWN Italian Society for Thrombosis and Haemostasis

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