Recombinant activated factor VII in the treatment of near-fatal bleeding during pediatric brain tumor surgery. Report of two cases and review of the literature

Journal of Neurosurgery
Matthias HartmannMartina Messing

Abstract

Recombinant activated factor VII (rFVIIa) was successfully used in two pediatric cases to control microvascular bleeding during brain tumor surgery. The agent demonstrated a marked effect on the intraoperative blood coagulation after failure of conventional therapy with fresh-frozen plasma, platelet concentrates, and inhibition of the fibrinolytic system. Remarkably, rFVIIa was effective in the present cases in which assessment of hemostasis yielded normal results. The use of rFVIIa should be considered in otherwise untreatable microvascular bleeding in pediatric neurosurgery.

References

Jan 1, 1995·Journal of Neurology, Neurosurgery, and Psychiatry·J D PalmerF Iannotti
Nov 5, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·K Y GohW S Poon
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Y ChengW K Cavenee
Jun 13, 2000·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·U Hedner
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·S HeU Hedner
Sep 26, 2003·Journal of Neurosurgical Anesthesiology·Dimitar KaradimovViliyan Platikanov
Oct 22, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Anders Dejgaard
Aug 21, 2004·Transfusion·Lawrence Tim GoodnoughCharles Eby
Feb 25, 2005·The New England Journal of Medicine·Stephan A MayerUNKNOWN Recombinant Activated Factor VII Intracerebral Hemorrhage Trial Investigators

❮ Previous
Next ❯

Citations

Jul 11, 2008·Journal of Neuro-oncology·Marco PiastraDomenico Pietrini
May 25, 2007·Neurocritical Care·Matthias Hartmann, Christoph Sucker
Aug 19, 2007·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Lynn UhrigPhilippe G Meyer
Nov 21, 2007·Surgery·A Grant Gerald
Mar 6, 2009·European Journal of Anaesthesiology·Thao T T NguyenRadboud W Koot

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.