Recombinant adenovirus-p53 enhances the therapeutic effect of surgery and chemoradiotherapy combination in hypopharyngeal squamous cell carcinomas patients

Medicine
Jun LiuHui Yang

Abstract

The purpose of our study was to assess the safety and efficacy of recombinant adenovirus-p53 (rAd-p53) combined with surgery and chemoradiotherapy (CRT) for patients with hypopharyngeal squamous cell carcinomas (HPSCC). This study retrospectively and consecutively collected clinical data of 102 patients with primary HPSCC who were admitted to the Department of Otolaryngology of West China Hospital, Sichuan University in China between March 2010 and December 2015. A retrospective clinical study of 102 patients with HPSCC was carried out from March 2010 to December 2015. All patients were male and were divided into 3 groups based on the treatments they received, including Single Surgery, Surgery + CRT, and Surgery + CRT + rAd-p53. In the Surgery + CRT + rAd-p53 group, rAd-p53 was intratumorally injected on the 1st day preoperatively; peritumorally injected on the 7th day intraoperatively, and on the 21st, 28th, and 35th days postoperatively. Their clinical data were retrospectively collected and analyzed. In our study, for all 102 patients with HPSCC, 16 patients received Single Surgery, 44 patients received Surgery + CRT therapy, and 42 patients received Surgery + CRT + rAd-p53 therapy. In the Surgery + CRT + rAd-p53 group, all ...Continue Reading

References

Mar 17, 2007·Acta Oto-laryngologica·Udi KatzenellEphraim Eviatar
May 15, 2012·Biochimica Et Biophysica Acta·Dorian R A SwartsErnst-Jan M Speel
Oct 17, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Patrick J Bradley
Jul 24, 2014·Journal of Surgical Oncology·Ryan BelcherAmy Y Chen
Jul 15, 2015·Cancer Epidemiology·Nut KoonrungsesomboonEvaristus Chibunna Mbanefo
Mar 6, 2016·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
Apr 21, 2018·European Annals of Otorhinolaryngology, Head and Neck Diseases·A DelagrandaF Rubin
May 20, 2018·Clinics in Laboratory Medicine·Muhammad ZulfiqarAmarpreet Bhalla

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Citations

Oct 1, 2020·International Journal of Molecular Sciences·Masakazu Hamada, Yoshiaki Yura

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS

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